@article{a29dd8130b1649288132047a365ca67a,
title = "A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer{\textquoteright}s disease",
abstract = "Alzheimer{\textquoteright}s disease (AD) is a looming public health disaster with limited interventions. Alzheimer{\textquoteright}s is a complex disease that can present with or without causative mutations and can be accompanied by a range of age-related comorbidities. This diverse presentation makes it difficult to study molecular changes specific to AD. To better understand the molecular signatures of disease we constructed a unique human brain sample cohort inclusive of autosomal dominant AD dementia (ADD), sporadic ADD, and those without dementia but with high AD histopathologic burden, and cognitively normal individuals with no/minimal AD histopathologic burden. All samples are clinically well characterized, and brain tissue was preserved postmortem by rapid autopsy. Samples from four brain regions were processed and analyzed by data-independent acquisition LC-MS/MS. Here we present a high-quality quantitative dataset at the peptide and protein level for each brain region. Multiple internal and external control strategies were included in this experiment to ensure data quality. All data are deposited in the ProteomeXchange repositories and available from each step of our processing.",
author = "Merrihew, {Gennifer E.} and Jea Park and Deanna Plubell and Searle, {Brian C.} and Keene, {C. Dirk} and Larson, {Eric B.} and Randall Bateman and Perrin, {Richard J.} and Chhatwal, {Jasmeer P.} and Farlow, {Martin R.} and McLean, {Catriona A.} and Bernardino Ghetti and Newell, {Kathy L.} and Frosch, {Matthew P.} and Montine, {Thomas J.} and MacCoss, {Michael J.}",
note = "Funding Information: Support for this research was provided by the National Institute of Aging (RF1 AG053959, U19 AG065156, F31 AG069420, R01 AG075802). The collection of tissue samples were supported by the UW Alzheimer{\textquoteright}s Disease Research Center (P30 AG066509), the Adult Changes in Thought study (U19 AG066567), the Nancy and Buster Alvord Endowment (C.D.K.), the Massachusetts Alzheimer Disease Research Center (P30 AG062421), The Dominantly Inherited Alzheimer Network (U19 AG032438, UF1AG032438), the German Center for Neurodegenerative Diseases (DZNE), Raul Carrea Institute for Neurological Research (FLENI), the Research and Development Grants for Dementia from Japan Agency for Medical Research and Development, AMED, and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI). This manuscript has been reviewed by DIAN Study investigators for scientific content and consistency of data interpretation with previous DIAN Study publications. We acknowledge the altruism of the participants and their families and contributions of the research and support staff at each of the participating sites for their contributions to this study. Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1038/s41597-023-02057-7",
language = "English",
volume = "10",
journal = "Scientific data",
issn = "2052-4463",
number = "1",
}