A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom

Ciprian Catana, Richard Laforest, Hongyu An, Fernando Boada, Tuoyu Cao, David Faul, Bjoern Jakoby, Floris P. Jansen, Bradley J. Kemp, Paul E. Kinahan, Peder Larson, Michael A. Levine, Piotr Maniawski, Osama Mawlawi, Jonathan E. McConathy, Alan B. McMillan, Julie C. Price, Abhejit Rajagopal, John Sunderland, Patrick Veit-HaibachKristen A. Wangerin, Chunwei Ying, Thomas A. Hope

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

PET/MRI scanners cannot be qualified in the manner adopted for hybrid PET/CT devices. The main hurdle with qualification in PET/MRI is that attenuation correction (AC) cannot be adequately measured in conventional PET phantoms because of the difficulty in converting the MR images of the physical structures (e.g., plastic) into electron density maps. Over the last decade, a plethora of novel MRI-based algorithms has been developed to more accurately derive the attenuation properties of the human head, including the skull. Although promising, none of these techniques has yet emerged as an optimal and universally adopted strategy for AC in PET/MRI. In this work, we propose a path for PET/MRI qualification for multicenter brain imaging studies. Specifically, our solution is to separate the head AC from the other factors that affect PET data quantification and use a patient as a phantom to assess the former. The emission data collected on the integrated PET/MRI scanner to be qualified should be reconstructed using both MRI- and CT-based AC methods, and whole-brain qualitative and quantitative (both voxelwise and regional) analyses should be performed. The MRI-based approach will be considered satisfactory if the PET quantification bias is within the acceptance criteria specified here. We have implemented this approach successfully across 2 PET/MRI scanner manufacturers at 2 sites.

Original languageEnglish
Pages (from-to)615-621
Number of pages7
JournalJournal of Nuclear Medicine
Volume63
Issue number4
DOIs
StatePublished - Apr 1 2022

Keywords

  • Attenuation correction
  • Multicenter trials
  • PET/MRI
  • Qualification

Fingerprint

Dive into the research topics of 'A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom'. Together they form a unique fingerprint.

Cite this