A novel Na_V1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias

Keyphrases

• Ventricular Arrhythmia 100%
• Voltage Sensor 100%
• Nav1.5 100%
• Atrial Arrhythmia 100%
• Lidocaine 75%
• Gating Pore Current 75%
• Loss Function 50%
• Voltage Dependence 50%
• Therapeutic Mechanism 25%
• Physiologic 25%
• Membrane Potential 25%
• Channel Activity 25%
• Patch Clamp 25%
• Hyperpolarized 25%
• Arrhythmia 25%
• Resting Membrane Potential 25%
• Recovery from Inactivation 25%
• Gain-of-function 25%
• Long QT Syndrome 25%
• Brugada Syndrome 25%
• Arrhythmia Syndromes 25%
• Transmembrane Segment 25%
• Cardiac NaV1.5 Channels 25%
• Recessive mutation 25%
• Inward Current 25%
• Complex Arrhythmias 25%
• Autosomal Dominant mutation 25%
• Na+ Current 25%
• Nav1.5 Channel 25%
• Voltage-clamp Fluorometry 25%
• Report Analysis 25%
• Channel Availability 25%

Biochemistry, Genetics and Molecular Biology

• Electric Potential 100%
• Cardiac Dysrhythmia 100%
• Nav1.5 100%
• Channel Gating 50%
• Lidocaine 50%
• Wild Type 16%
• Autosomal Dominant Inheritance 16%
• Membrane Potential 16%
• Sodium Channel 16%
• Induced Mutation 16%
• Long QT Syndrome 16%
• Voltage Clamp 16%
• Membrane Steady Potential 16%
• Patch Clamp 16%
• Brugada Syndrome 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Heart Ventricle Arrhythmia 100%
• Heart Atrium Arrhythmia 100%
• Lidocaine 100%
• Heart Arrhythmia 66%
• Sodium Channel Nav1.5 66%
• Sodium Ion 33%
• Syndrome 33%
• Long QT Syndrome 33%
• Brugada Syndrome 33%