A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis

Kristin L. Griffiths; Daniel O. Villarreal; David B. Weiner; Shabaana A. Khader

doi:10.1080/21645515.2016.1197454

A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis

Kristin L. Griffiths
, Daniel O. Villarreal
, David B. Weiner
, Shabaana A. Khader

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Mycobacterium tuberculosis infects one third of the world's population. Due to variable efficacy of the Bacille Calmette Guerin (BCG) vaccine, development of novel TB vaccines remains a priority. Here, we demonstrate the protective efficacy of a novel multivalent DNA vaccine, which contains 15 synthetic antigens targeting the Mtb ESX secretion system.

Original language	English
Pages (from-to)	2649-2653
Number of pages	5
Journal	Human Vaccines and Immunotherapeutics
Volume	12
Issue number	10
DOIs	https://doi.org/10.1080/21645515.2016.1197454
State	Published - Oct 2 2016

Keywords

DNA vaccine
Tuberculosis
vaccine

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10.1080/21645515.2016.1197454

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title = "A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis",

abstract = "Mycobacterium tuberculosis infects one third of the world's population. Due to variable efficacy of the Bacille Calmette Guerin (BCG) vaccine, development of novel TB vaccines remains a priority. Here, we demonstrate the protective efficacy of a novel multivalent DNA vaccine, which contains 15 synthetic antigens targeting the Mtb ESX secretion system.",

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AU - Khader, Shabaana A.

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AB - Mycobacterium tuberculosis infects one third of the world's population. Due to variable efficacy of the Bacille Calmette Guerin (BCG) vaccine, development of novel TB vaccines remains a priority. Here, we demonstrate the protective efficacy of a novel multivalent DNA vaccine, which contains 15 synthetic antigens targeting the Mtb ESX secretion system.

KW - DNA vaccine

KW - Tuberculosis

KW - vaccine

UR - https://www.scopus.com/pages/publications/84979703599

U2 - 10.1080/21645515.2016.1197454

DO - 10.1080/21645515.2016.1197454

M3 - Article

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AN - SCOPUS:84979703599

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A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis

Abstract

Keywords

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