A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis

Kristin L. Griffiths, Daniel O. Villarreal, David B. Weiner, Shabaana A. Khader

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Mycobacterium tuberculosis infects one third of the world's population. Due to variable efficacy of the Bacille Calmette Guerin (BCG) vaccine, development of novel TB vaccines remains a priority. Here, we demonstrate the protective efficacy of a novel multivalent DNA vaccine, which contains 15 synthetic antigens targeting the Mtb ESX secretion system.

Original languageEnglish
Pages (from-to)2649-2653
Number of pages5
JournalHuman Vaccines and Immunotherapeutics
Volume12
Issue number10
DOIs
StatePublished - Oct 2 2016

Keywords

  • DNA vaccine
  • Tuberculosis
  • vaccine

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