A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing

Marina Cella, Christian Döhring, Jacqueline Samaridis, Mark Dessing, Manfred Brockhaus, Antonio Lanzavecchia, Marco Colonna

Research output: Contribution to journalArticlepeer-review

351 Scopus citations

Abstract

Immunoglobulin-like transcript (ILT) 3 is a novel cell surface molecule of the immunoglobulin superfamily, which is selectively expressed by myeloid antigen presenting cells (APCs) such as monocytes, macrophages, and dendritic cells. The cytoplasmic region of ILT3 contains putative immunoreceptor tyrosine-based inhibitory motifs that suggest an inhibitory function of ILT3. Indeed, co-ligation of ILT3 to stimulatory/receptors expressed by APCs results in a dramatic blunting of the increased [Ca2+](i) and tyrosine phosphorylation triggered by these receptors. Signal extinction involves SH2- containing protein tyrosine phosphatase 1, which is recruited by ILT3 upon cross linking. ILT3 can also function in antigen capture and presentation. It is efficiently internalized upon cross-linking, and delivers its ligand to an intracellular compartment where it is processed and presented to T cells. Thus, ILT3 is a novel inhibitory receptor that can negatively regulate activation of APCs and can be used by APCs for antigen uptake.

Original languageEnglish
Pages (from-to)1743-1752
Number of pages10
JournalJournal of Experimental Medicine
Volume185
Issue number10
DOIs
StatePublished - May 19 1997

Fingerprint

Dive into the research topics of 'A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing'. Together they form a unique fingerprint.

Cite this