TY - JOUR
T1 - A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan
AU - Xu, Wangchao
AU - Rustenhoven, Justin
AU - Nelson, Christopher A.
AU - Dykstra, Taitea
AU - Ferreiro, Aura
AU - Papadopoulos, Zachary
AU - Burnham, Carey Ann D.
AU - Dantas, Gautam
AU - Fremont, Daved H.
AU - Kipnis, Jonathan
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/10/18
Y1 - 2023/10/18
N2 - Aging is a complex process involving various systems and behavioral changes. Altered immune regulation, dysbiosis, oxidative stress, and sleep decline are common features of aging, but their interconnection is poorly understood. Using Drosophila, we discover that IM33, a novel immune modulator, and its mammalian homolog, secretory leukocyte protease inhibitor (SLPI), are upregulated in old flies and old mice, respectively. Knockdown of IM33 in glia elevates the gut reactive oxygen species (ROS) level and alters gut microbiota composition, including increased Lactiplantibacillus plantarum abundance, leading to a shortened lifespan. Additionally, dysbiosis induces sleep fragmentation through the activation of insulin-producing cells in the brain, which is mediated by the binding of Lactiplantibacillus plantarum-produced DAP-type peptidoglycan to the peptidoglycan recognition protein LE (PGRP-LE) receptor. Therefore, IM33 plays a role in the glia-microbiota-neuronal axis, connecting neuroinflammation, dysbiosis, and sleep decline during aging. Identifying molecular mediators of these processes could lead to the development of innovative strategies for extending lifespan.
AB - Aging is a complex process involving various systems and behavioral changes. Altered immune regulation, dysbiosis, oxidative stress, and sleep decline are common features of aging, but their interconnection is poorly understood. Using Drosophila, we discover that IM33, a novel immune modulator, and its mammalian homolog, secretory leukocyte protease inhibitor (SLPI), are upregulated in old flies and old mice, respectively. Knockdown of IM33 in glia elevates the gut reactive oxygen species (ROS) level and alters gut microbiota composition, including increased Lactiplantibacillus plantarum abundance, leading to a shortened lifespan. Additionally, dysbiosis induces sleep fragmentation through the activation of insulin-producing cells in the brain, which is mediated by the binding of Lactiplantibacillus plantarum-produced DAP-type peptidoglycan to the peptidoglycan recognition protein LE (PGRP-LE) receptor. Therefore, IM33 plays a role in the glia-microbiota-neuronal axis, connecting neuroinflammation, dysbiosis, and sleep decline during aging. Identifying molecular mediators of these processes could lead to the development of innovative strategies for extending lifespan.
KW - Drosophila
KW - IM33
KW - brain-gut axis
KW - glia-gut axis
KW - longevity
KW - neuroimmunology
UR - http://www.scopus.com/inward/record.url?scp=85173716359&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2023.07.010
DO - 10.1016/j.neuron.2023.07.010
M3 - Article
C2 - 37582366
AN - SCOPUS:85173716359
SN - 0896-6273
VL - 111
SP - 3244-3254.e8
JO - Neuron
JF - Neuron
IS - 20
ER -