A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma

Fumihiko Urano, Akihiro Umezawa, Wei Hong, Haruhito Kikuchi, Jun Ichi Hata

Research output: Contribution to journalArticle

144 Scopus citations

Abstract

Ewing's sarcoma/PNET, a tumor of the bone and soft tissue, is one of the most common causes of tumor death among youths. This tumor does not have specific phenotypes, but does have characteristic chromosomal translocations. Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was found to be generated through a t(11;22)(q24;q12) or a t(21;22)(q22;q12) translocation. In this study, we identified a new chimera gene between the transactivation domain of EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein. Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET.

Original languageEnglish
Pages (from-to)608-612
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume219
Issue number2
DOIs
StatePublished - Feb 15 1996
Externally publishedYes

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