TY - JOUR
T1 - A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma
AU - Urano, Fumihiko
AU - Umezawa, Akihiro
AU - Hong, Wei
AU - Kikuchi, Haruhito
AU - Hata, Jun Ichi
N1 - Funding Information:
We dedicate this article to Dr. T. Hirata, our colleague, who died of PNET in 1993. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan and a Cancer Research Grant from the Ministry of Health and Welfare, together with funds provided by the Entrustment of Research Program of the Foundation for Promotion of Cancer Research of Japan and by the Vehicle Racing Commemorative Foundation. The nucleotide sequence of the EWS/E1A-F chimera cDNA has been deposited in the GenBank database (Accession No. U35622).
PY - 1996/2/15
Y1 - 1996/2/15
N2 - Ewing's sarcoma/PNET, a tumor of the bone and soft tissue, is one of the most common causes of tumor death among youths. This tumor does not have specific phenotypes, but does have characteristic chromosomal translocations. Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was found to be generated through a t(11;22)(q24;q12) or a t(21;22)(q22;q12) translocation. In this study, we identified a new chimera gene between the transactivation domain of EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein. Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET.
AB - Ewing's sarcoma/PNET, a tumor of the bone and soft tissue, is one of the most common causes of tumor death among youths. This tumor does not have specific phenotypes, but does have characteristic chromosomal translocations. Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was found to be generated through a t(11;22)(q24;q12) or a t(21;22)(q22;q12) translocation. In this study, we identified a new chimera gene between the transactivation domain of EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein. Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET.
UR - http://www.scopus.com/inward/record.url?scp=0029927373&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1996.0281
DO - 10.1006/bbrc.1996.0281
M3 - Article
C2 - 8605035
AN - SCOPUS:0029927373
SN - 0006-291X
VL - 219
SP - 608
EP - 612
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -