A normative spatiotemporal MRI atlas of the fetal brain for automatic segmentation and analysis of early brain growth

Ali Gholipour, Caitlin K. Rollins, Clemente Velasco-Annis, Abdelhakim Ouaalam, Alireza Akhondi-Asl, Onur Afacan, Cynthia M. Ortinau, Sean Clancy, Catherine Limperopoulos, Edward Yang, Judy A. Estroff, Simon K. Warfield

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Longitudinal characterization of early brain growth in-utero has been limited by a number of challenges in fetal imaging, the rapid change in size, shape and volume of the developing brain, and the consequent lack of suitable algorithms for fetal brain image analysis. There is a need for an improved digital brain atlas of the spatiotemporal maturation of the fetal brain extending over the key developmental periods. We have developed an algorithm for construction of an unbiased four-dimensional atlas of the developing fetal brain by integrating symmetric diffeomorphic deformable registration in space with kernel regression in age. We applied this new algorithm to construct a spatiotemporal atlas from MRI of 81 normal fetuses scanned between 19 and 39 weeks of gestation and labeled the structures of the developing brain. We evaluated the use of this atlas and additional individual fetal brain MRI atlases for completely automatic multi-atlas segmentation of fetal brain MRI. The atlas is available online as a reference for anatomy and for registration and segmentation, to aid in connectivity analysis, and for groupwise and longitudinal analysis of early brain growth.

Original languageEnglish
Article number476
JournalScientific reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint Dive into the research topics of 'A normative spatiotemporal MRI atlas of the fetal brain for automatic segmentation and analysis of early brain growth'. Together they form a unique fingerprint.

  • Cite this

    Gholipour, A., Rollins, C. K., Velasco-Annis, C., Ouaalam, A., Akhondi-Asl, A., Afacan, O., Ortinau, C. M., Clancy, S., Limperopoulos, C., Yang, E., Estroff, J. A., & Warfield, S. K. (2017). A normative spatiotemporal MRI atlas of the fetal brain for automatic segmentation and analysis of early brain growth. Scientific reports, 7(1), [476]. https://doi.org/10.1038/s41598-017-00525-w