A nomenclature system for the aldo-keto reductase superfamily

Joseph M. Jez, T. Geoffrey Flynn, Trevor M. Penning

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


As new members of the AKR superfamily are identified the need for a systematic and expandable nomenclature has risen, especially since some members of the superfamily have multiple names based on substrate specificity. We have proposed a nomenclature system for the AKR superfamily that is similar to the P450 system but based on amino acid sequence comparisons instead of nucleotide sequence comparisons. Our system uses percent amino acid identities to delineate families and subfamilies within the larger superfamily. Although there are not as many AKRs as P450s, having a flexible nomenclature system will allow for easy incorporation of new proteins into the superfamily.

Original languageEnglish
Pages (from-to)579-589
Number of pages11
JournalAdvances in Experimental Medicine and Biology
StatePublished - 1997


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