A new stain for quantitative measurement of sprouting at neuromuscular junctions

Alan Pestronk, Daniel B. Drachman

Research output: Contribution to journalArticlepeer-review

139 Scopus citations

Abstract

A new combined stain for the simultaneous demonstration of motor nerve terminals and cholinesterase at neuromuscular junctions is described. It employs bromoindoxyl acetate dye‐staining for cholinesterase and silver‐gold impregnation for nerve terminals. The clarity and reliability of the stain permit quantitative measurements of neuromuscular junctions in order to evaluate nerve terminal sprouting as well as other pathological changes. The method is rapid, reproducible, and simple, and it is well suited for the processing of large numbers of frozen sections.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalMuscle & Nerve
Volume1
Issue number1
DOIs
StatePublished - 1978

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