A new family of 2-hydroxyacid dehydrogenases

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Abstract

The NADH-dependent hydroxypyruvate reductase from cucumber and the pdxB gene product of E. coli display significant homology to E. coli D-3-phosphoglycerate dehydrogenase. In contrast, these proteins do not display much similarity with other oxidoreductases or with other 2-hydroxyacid dehydrogenases in particular. On the basis of their relatedness and the structure of their substrates, these three enzymes constitute a new family of 2-hydroxyacid dehydrogenases distinct from malate and lactate dehydrogenase.

Original languageEnglish
Pages (from-to)1371-1374
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume165
Issue number3
DOIs
StatePublished - Dec 30 1989

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