TY - JOUR
T1 - A Network representation of response probability in the striatum
AU - Blazquez, Pablo M.
AU - Fujii, Naotaka
AU - Kojima, Jun
AU - Graybiel, Ann M.
N1 - Funding Information:
This work was supported by a Javits award (NIH/NINDS R01 NS25529), the National Parkinson Foundation, the Stanley Foundation, and the A.A. Scottish Rite Schizophrenia Research Program. We thank Dr. Mikael Djurfeldt and Dr. Paul DiZio for their valuable help with the data analysis, Dr. Richard Courtemanche for participating in some experiments, and Dr. Bruce Jenkins and Dr. Robert Marini for help with MRI acquisition.
PY - 2002/3/14
Y1 - 2002/3/14
N2 - The striatum of the basal ganglia is considered a key structure in the learning circuitry of the brain. To analyze neural signals that underlie striatal plasticity, we recorded from an identifiable class of striatal interneurons as macaque monkeys underwent training in a range of conditioning and non-associative learning paradigms, and recorded eyeblink electromyographs as the measure of behavioral response. We found that the responses of these striatal interneurons were modifiable under all training conditions and that their population responses were tightly correlated with the probability that a given stimulus would evoke a behavioral response. Such a network signal, proportional to current response probability, could be crucial to the learning and decision functions of the basal ganglia.
AB - The striatum of the basal ganglia is considered a key structure in the learning circuitry of the brain. To analyze neural signals that underlie striatal plasticity, we recorded from an identifiable class of striatal interneurons as macaque monkeys underwent training in a range of conditioning and non-associative learning paradigms, and recorded eyeblink electromyographs as the measure of behavioral response. We found that the responses of these striatal interneurons were modifiable under all training conditions and that their population responses were tightly correlated with the probability that a given stimulus would evoke a behavioral response. Such a network signal, proportional to current response probability, could be crucial to the learning and decision functions of the basal ganglia.
UR - http://www.scopus.com/inward/record.url?scp=0037075541&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(02)00627-X
DO - 10.1016/S0896-6273(02)00627-X
M3 - Article
C2 - 11906702
AN - SCOPUS:0037075541
SN - 0896-6273
VL - 33
SP - 973
EP - 982
JO - Neuron
JF - Neuron
IS - 6
ER -