A national human neuroimaging collaboratory enabled by the biomedical informatics research network (BIRN)

David B. Keator, J. S. Grethe, D. Marcus, B. Ozyurt, S. Gadde, Sean Murphy, S. Pieper, Pieper D. Greve, R. Notestine, H. J. Bockholt, P. Papadopoulos

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


The aggregation of imaging, clinical, and behavioral data from multiple independent institutions and researchers presents both a great opportunity for biomedical research as well as a formidable challenge. Many research groups have well-established data collection and analysis procedures, as well as data and metadata format requirements that are particular to that group. Moreover, the types of data and metadata collected are quite diverse, including image, physiological, and behavioral data, as well as descriptions of experimental design, and preprocessing and analysis methods. Each of these types of data utilizes a variety of software tools for collection, storage, and processing. Furthermore sites are reluctant to release control over the distribution and access to the data and the tools. To address these needs, the Biomedical Informatics Research Network (BIRN) has developed a federated and distributed infrastructure for the storage, retrieval, analysis, and documentation of biomedical imaging data. The infrastructure consists of distributed data collections hosted on dedicated storage and computational resources located at each participating site, a federated data management system and data integration environment, an Extensible Markup Language (XML) schema for data exchange, and analysis pipelines, designed to leverage both the distributed data management environment and the available grid computing resources.

Original languageEnglish
Pages (from-to)162-172
Number of pages11
JournalIEEE Transactions on Information Technology in Biomedicine
Issue number2
StatePublished - Mar 2008


  • BIRN
  • Biomedical Informatics Research Network (BIRN)
  • Cyberinfrastructure
  • Data grid
  • Database
  • Extensible Markup Language (XML)
  • Extensible Markup Language (XML)-based clinical experiment data exchange schema (XCEDE)
  • Extensible Neuroimaging Archive Toolkit (XNAT)
  • Globus
  • HID
  • High intensity discharge (HID)
  • Informatics
  • MRI
  • Magnetic resonance imaging (MRI)
  • Neuroimage
  • SRB
  • Storage resources broker (SRB)
  • XML
  • XNAT


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