A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion

Swapneel J. Patel, Guoyan Zhao, Vinay R. Penna, Eugene Park, Elvin J. Lauron, Ian B. Harvey, Wandy L. Beatty, Beatrice Plougastel-Douglas, Jennifer Poursine-Laurent, Daved H. Fremont, David Wang, Wayne M. Yokoyama

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many diseases; however, it has been challenging to establish infections with roseoloviruses as direct drivers of pathology, because they are nearly ubiquitous and display species-specific tropism. Furthermore, controlled study of infection has been hampered by the lack of experimental models, and until now, a mouse roseolovirus has not been identified. Herein we describe a virus that causes severe thymic necrosis in neonatal mice, characterized by a loss of CD4+ T cells. These phenotypes resemble those caused by the previously described mouse thymic virus (MTV), a putative herpesvirus that has not been molecularly characterized. By next-generation sequencing of infected tissue homogenates, we assembled a contiguous 174-kb genome sequence containing 128 unique predicted open reading frames (ORFs), many of which were most closely related to herpesvirus genes. Moreover, the structure of the virus genome and phylogenetic analysis of multiple genes strongly suggested that this virus is a betaherpesvirus more closely related to the roseoloviruses, HHV-6A, HHV-6B, and HHV-7, than to another murine betaherpesvirus, mouse cytomegalovirus (MCMV). As such, we have named this virus murine roseolovirus (MRV) because these data strongly suggest that MRV is a mouse homolog of HHV-6A, HHV-6B, and HHV-7.

Original languageEnglish
Article numbere02463-16
JournalJournal of virology
Volume91
Issue number9
DOIs
StatePublished - May 1 2017

Keywords

  • Herpesviruses
  • Roseolovirus

Fingerprint Dive into the research topics of 'A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion'. Together they form a unique fingerprint.

  • Cite this