TY - GEN
T1 - A multiplexed biosensor based on biomolecular nanowires
AU - Liu, Yang
AU - Chakrabartty, Shantanu
AU - Alocilja, Evangelyn C.
PY - 2008
Y1 - 2008
N2 - In this paper we describe the fabrication and characterization of a multiplexed biosensor based on molecular bio-wires that can be used for detecting multiple pathogens in a biological sample. At the core of the proposed device is a biosensor that operates by converting binding events between antigen and antibody into a measurable electrical signal using polyaniline nanowires as transducers. By mixing and patterning antibodies at different spatial locations of the biosensor, the response of the biosensor can be configured to detect the presence of either one of several pathogens present in the analyte, thus making it ideal for rapid environment screening applications. Experiments using the biosensor array specific to B. cereus and E. coli bacteria validate the functionality of the proposed multiplexed architecture.
AB - In this paper we describe the fabrication and characterization of a multiplexed biosensor based on molecular bio-wires that can be used for detecting multiple pathogens in a biological sample. At the core of the proposed device is a biosensor that operates by converting binding events between antigen and antibody into a measurable electrical signal using polyaniline nanowires as transducers. By mixing and patterning antibodies at different spatial locations of the biosensor, the response of the biosensor can be configured to detect the presence of either one of several pathogens present in the analyte, thus making it ideal for rapid environment screening applications. Experiments using the biosensor array specific to B. cereus and E. coli bacteria validate the functionality of the proposed multiplexed architecture.
KW - Biosensors
KW - Environmental monitoring
KW - Multiplexed detection
KW - Polyaniline
UR - http://www.scopus.com/inward/record.url?scp=51749118916&partnerID=8YFLogxK
U2 - 10.1109/ISCAS.2008.4541840
DO - 10.1109/ISCAS.2008.4541840
M3 - Conference contribution
AN - SCOPUS:51749118916
SN - 9781424416844
T3 - Proceedings - IEEE International Symposium on Circuits and Systems
SP - 2006
EP - 2009
BT - 2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008
T2 - 2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008
Y2 - 18 May 2008 through 21 May 2008
ER -