A multimodality image-based fluid-structure interaction modeling approach for prediction of coronary plaque progression using ivus and optical coherence tomography data with follow-up

Xiaoya Guo, Don P. Giddens, David Molony, Chun Yang, Habib Samady, Jie Zheng, Mitsuaki Matsumura, Gary S. Mintz, Akiko Maehara, Liang Wang, Dalin Tang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Medical image resolution has been a serious limitation in plaque progression research. A modeling approach combining intravascular ultrasound (IVUS) and optical coherence tomography (OCT) was introduced and patient follow-up IVUS and OCT data were acquired to construct three-dimensional (3D) coronary models for plaque progression investigations. Baseline and follow-up in vivo IVUS and OCT coronary plaque data were acquired from one patient with 105 matched slices selected for model construction. 3D fluid-structure interaction (FSI) models based on IVUS and OCT data (denoted as IVUSOCT model) were constructed to obtain stress/strain and wall shear stress (WSS) for plaque progression prediction. IVUS-based IVUS50 and IVUS200 models were constructed for comparison with cap thickness set as 50 and 200 lm, respectively. Lumen area increase (LAI), plaque area increase (PAI), and plaque burden increase (PBI) were chosen to measure plaque progression. The least squares support vector machine (LSSVM) method was employed for plaque progression prediction using 19 risk factors. For IVUSOCT model with LAI, PAI, and PBI, the best single predictor was plaque strain, local plaque stress, and minimal cap thickness, with prediction accuracy as 0.766, 0.838, and 0.890, respectively; the prediction accuracy using best combinations of 19 factors was 0.911, 0.881, and 0.905, respectively. Compared to IVUSOCT model, IVUS50, and IVUS200 models had errors ranging from 1% to 66.5% in quantifying cap thickness, stress, strain and prediction accuracies. WSS showed relatively lower prediction accuracy compared to other predictors in all nine prediction studies

Original languageEnglish
Article number091003
JournalJournal of Biomechanical Engineering
Volume141
Issue number9
DOIs
StatePublished - Sep 2019

Keywords

  • Fsi
  • Ivus
  • OCT
  • Patient-specific model
  • Plaque progression
  • Vulnerable plaque

Fingerprint

Dive into the research topics of 'A multimodality image-based fluid-structure interaction modeling approach for prediction of coronary plaque progression using ivus and optical coherence tomography data with follow-up'. Together they form a unique fingerprint.

Cite this