A Multicenter Study on Observed Discrepancies Between Vendor-Stated and PET-Measured 90Y Activities for Both Glass and Resin Microsphere Devices

Silvano Gnesin, Justin K. Mikell, Maurizio Conti, John O. Prior, Thomas Carlier, Thiago V.M. Lima, Yuni K. Dewaraja

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Dosimetry-guided treatment planning in selective internal radiation therapy relies on accurate and reproducible measurement of administered activity. This 4-center, 5-PET-device study compared the manufacturer-declared 90Y activity in vials with quantitative 90Y PET/CT assessment of the same vials. We compared 90Y PET-measured activity (APET) for 56 90Y-labeled glass and 18 90Y-labeled resin microsphere vials with the calibrated activity specified by the manufacturer (AM). Additionally, the same analysis was performed for 4 90Y-chloride vials. The mean APET/AM ratio was 0.79 ± 0.04 (range, 0.71-0.89) for glass microspheres and 1.15 ± 0.06 (range, 1.05-1.25) for resin microspheres. The mean APET/AM ratio for 90Y-chloride vials was 1.00 ± 0.04 (range, 0.96-1.06). Thus, we found an average difference of 46% between glass and resin microsphere activity calibrations, whereas close agreement was found for chloride solutions. We expect that the reported discrepancies will promote further investigations to establish reliable and accurate patient dosimetry and dose-effect assessments.

Original languageEnglish
Pages (from-to)825-828
Number of pages4
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume64
Issue number5
DOIs
StatePublished - May 1 2023

Keywords

  • 90Y
  • PET/CT
  • activity
  • glass microspheres
  • resin microspheres

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