TY - JOUR
T1 - A multicenter study of Clostridium difficile infection-related colectomy, 2000-2006
AU - Kasper, Amelia M.
AU - Nyazee, Humaa A.
AU - Yokoe, Deborah S.
AU - Mayer, Jeanmarie
AU - Mangino, Julie E.
AU - Khan, Yosef M.
AU - Hota, Bala
AU - Fraser, Victoria J.
AU - Dubberke, Erik R.
PY - 2012/5
Y1 - 2012/5
N2 - objective. To assess Clostridium difficile infection (CDI)-related colectomy rates by CDI surveillance definitions and over time at multiple healthcare facilities. setting. Five university-affiliated acute care hospitals in the United States. design and methods. Cases of CDI and patients who underwent colectomy from July 2000 through June 2006 were identified from 5 US tertiary care centers. Monthly CDI-related colectomy rates were calculated as the number of CDI-related colectomies per 1,000 CDI cases, and cases were categorized according to recommended surveillance definitions. Logistic regression was performed to evaluate risk factors for CDI-related colectomy. results. In total, 8,569 cases of CDI were identified, and 75 patients underwent CDI-related colectomy. The overall colectomy rate was 8.7 per 1,000 CDI cases. The CDI-related colectomy rate ranged from 0 to 23 per 1,000 CDI episodes across hospitals. The colectomy rate for healthcare-facility-onset CDI was 4.3 per 1,000 CDI cases, and that for community-onset CDI was 16.5 per 1,000 CDI cases (P<.05). There were significantly more CDI-related colectomies at hospitals B and C (P<.05). conclusions. The overall CDI-related colectomy rate was low, and there was no significant change in the CDI-related colectomy rate over time. Onset of disease outside the study hospital was an independent risk factor for colectomy.
AB - objective. To assess Clostridium difficile infection (CDI)-related colectomy rates by CDI surveillance definitions and over time at multiple healthcare facilities. setting. Five university-affiliated acute care hospitals in the United States. design and methods. Cases of CDI and patients who underwent colectomy from July 2000 through June 2006 were identified from 5 US tertiary care centers. Monthly CDI-related colectomy rates were calculated as the number of CDI-related colectomies per 1,000 CDI cases, and cases were categorized according to recommended surveillance definitions. Logistic regression was performed to evaluate risk factors for CDI-related colectomy. results. In total, 8,569 cases of CDI were identified, and 75 patients underwent CDI-related colectomy. The overall colectomy rate was 8.7 per 1,000 CDI cases. The CDI-related colectomy rate ranged from 0 to 23 per 1,000 CDI episodes across hospitals. The colectomy rate for healthcare-facility-onset CDI was 4.3 per 1,000 CDI cases, and that for community-onset CDI was 16.5 per 1,000 CDI cases (P<.05). There were significantly more CDI-related colectomies at hospitals B and C (P<.05). conclusions. The overall CDI-related colectomy rate was low, and there was no significant change in the CDI-related colectomy rate over time. Onset of disease outside the study hospital was an independent risk factor for colectomy.
UR - http://www.scopus.com/inward/record.url?scp=84859363607&partnerID=8YFLogxK
U2 - 10.1086/665318
DO - 10.1086/665318
M3 - Article
C2 - 22476273
AN - SCOPUS:84859363607
SN - 0899-823X
VL - 33
SP - 470
EP - 476
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
IS - 5
ER -