A multi spectral hand-held spatial frequency domain imaging system for imaging human colorectal cancer

Yifeng Zeng, Shuying Li, Mohsen Erfanzadeh, Sreyankar Nandy, William Chapman, Zahra Alipour, Heba Abdelal, Deyali Chatterjee, Matthew Mutch, Quing Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A multi-spectral, portable, hand-held LED based spatial frequency domain imaging system was used for ex vivo imaging pretreatment and post treatment human colon and rectal tissues. Freshly excised human colon and rectal tissue samples were imaged with the hand-held SFDI probe with 9 wavelengths extending from visible to NIR (660-950 nm). Important tumor biomarkers such as hemoglobin, scatter amplitude, scatter spectral slope, water and lipid content were quantitatively extracted from the SFDI absorption and scattering images. Significant differences were observed between the absorption as well as scattering distribution of normal, tumor and polyp tissue as well as between pretreated and post-Treated tumors.

Original languageEnglish
Title of host publicationOptical Tomography and Spectroscopy of Tissue XIII
EditorsSergio Fantini, Paola Taroni
PublisherSPIE
ISBN (Electronic)9781510623903
DOIs
StatePublished - 2019
EventOptical Tomography and Spectroscopy of Tissue XIII 2019 - San Francisco, United States
Duration: Feb 4 2019Feb 6 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10874
ISSN (Print)1605-7422

Conference

ConferenceOptical Tomography and Spectroscopy of Tissue XIII 2019
CountryUnited States
CitySan Francisco
Period02/4/1902/6/19

Keywords

  • Colorectal
  • Diffuse optical imaging
  • Imaging systems
  • Structured light
  • Tissue optics
  • Tumor

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