A multi-channel femtoampere-sensitivity conductometric array for biosensing applications

Amit Gore, Shantanu Chakrabartty, Sudeshna Pal, Evangelyn Alocilja

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

13 Scopus citations

Abstract

Rapid detection of pathogens using field deployable biosensors requires integrated sensing and data processing. Detection of low concentration of biological agents is possible using accurate and real-time signal characterization devices. This paper presents a multi-channel conductometric array that can detect and measure current up to femtoampere range. The architecture uses a novel semi-synchronous ΣΔ modulation that allows measurement of ultra-small currents by using a hysteretic comparison technique. The architecture achieves higher energy efficiency over a conventional ΣΔ by reducing the total switching cycles of the comparator. A 3 mm × 3 mm chip implementing a 42 channel potentiostat array has been prototyped in a 0.5μm CMOS technology. Measured results show 10 bits of resolution, with a sensitivity of upto 50 fA of current. The power consumption of the potentiostat is 11μW per channel at a sampling rate of 250 kHz. The multi-channel potentiostat has been integrated with a conductometric biosensor for field deployable applications. Results with a Bacillus Cereus based biosensor demonstrate the effectiveness of the potentiostat in characterizing different concentration levels of pathogens in real-time.

Original languageEnglish
Title of host publication28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages6489-6492
Number of pages4
DOIs
StatePublished - 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Conference

Conference28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Country/TerritoryUnited States
CityNew York, NY
Period08/30/0609/3/06

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