TY - GEN
T1 - A multi-channel femtoampere-sensitivity conductometric array for biosensing applications
AU - Gore, Amit
AU - Chakrabartty, Shantanu
AU - Pal, Sudeshna
AU - Alocilja, Evangelyn
PY - 2006
Y1 - 2006
N2 - Rapid detection of pathogens using field deployable biosensors requires integrated sensing and data processing. Detection of low concentration of biological agents is possible using accurate and real-time signal characterization devices. This paper presents a multi-channel conductometric array that can detect and measure current up to femtoampere range. The architecture uses a novel semi-synchronous ΣΔ modulation that allows measurement of ultra-small currents by using a hysteretic comparison technique. The architecture achieves higher energy efficiency over a conventional ΣΔ by reducing the total switching cycles of the comparator. A 3 mm × 3 mm chip implementing a 42 channel potentiostat array has been prototyped in a 0.5μm CMOS technology. Measured results show 10 bits of resolution, with a sensitivity of upto 50 fA of current. The power consumption of the potentiostat is 11μW per channel at a sampling rate of 250 kHz. The multi-channel potentiostat has been integrated with a conductometric biosensor for field deployable applications. Results with a Bacillus Cereus based biosensor demonstrate the effectiveness of the potentiostat in characterizing different concentration levels of pathogens in real-time.
AB - Rapid detection of pathogens using field deployable biosensors requires integrated sensing and data processing. Detection of low concentration of biological agents is possible using accurate and real-time signal characterization devices. This paper presents a multi-channel conductometric array that can detect and measure current up to femtoampere range. The architecture uses a novel semi-synchronous ΣΔ modulation that allows measurement of ultra-small currents by using a hysteretic comparison technique. The architecture achieves higher energy efficiency over a conventional ΣΔ by reducing the total switching cycles of the comparator. A 3 mm × 3 mm chip implementing a 42 channel potentiostat array has been prototyped in a 0.5μm CMOS technology. Measured results show 10 bits of resolution, with a sensitivity of upto 50 fA of current. The power consumption of the potentiostat is 11μW per channel at a sampling rate of 250 kHz. The multi-channel potentiostat has been integrated with a conductometric biosensor for field deployable applications. Results with a Bacillus Cereus based biosensor demonstrate the effectiveness of the potentiostat in characterizing different concentration levels of pathogens in real-time.
UR - http://www.scopus.com/inward/record.url?scp=34047135085&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.260865
DO - 10.1109/IEMBS.2006.260865
M3 - Conference contribution
AN - SCOPUS:34047135085
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 6489
EP - 6492
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -