@inbook{19d2785dbe24464da2aa10f5af451f94,
title = "A mouse model of necrotizing enterocolitis",
abstract = "Necrotizing enterocolitis (NEC) is an acute inflammatory disease that unforeseeably develops in very low birth weight premature infants. NEC is characterized by impairment of the intestinal barrier resulting in intestinal necrosis and multisystem organ failure. Animal models of NEC have contributed significantly to a better understanding of the underlying molecular mechanisms of the disease and facilitated the exploration of potential new therapeutic strategies. Here, we provide a detailed protocol that recapitulates some of the main histological and transcriptional features of human NEC in newborn mice.",
keywords = "Enteric bacteria, Intestinal inflammation, Mucosal barrier, Necrotizing enterocolitis, Neonatal mice",
author = "Belgacem Mihi and Lanik, {Wyatt E.} and Qingqing Gong and Misty Good",
note = "Funding Information: MG is supported by grants K08DK101608, R03DK111473, and R01DK118568 from the National Institutes of Health, March of Dimes Foundation Grant No. 5-FY17-79, the Children{\textquoteright}s Discovery Institute of Washington University and St. Louis Children{\textquoteright}s Hospital, and the Department of Pediatrics at Washington University School of Medicine, St. Louis. Belgacem Mihi, Wyatt E. Lanik, and Qingqing Gong contributed equally to this work. Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2021.",
year = "2021",
doi = "10.1007/978-1-0716-1488-4_9",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "101--110",
booktitle = "Methods in Molecular Biology",
}