A mouse model of necrotizing enterocolitis

Belgacem Mihi, Wyatt E. Lanik, Qingqing Gong, Misty Good

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Necrotizing enterocolitis (NEC) is an acute inflammatory disease that unforeseeably develops in very low birth weight premature infants. NEC is characterized by impairment of the intestinal barrier resulting in intestinal necrosis and multisystem organ failure. Animal models of NEC have contributed significantly to a better understanding of the underlying molecular mechanisms of the disease and facilitated the exploration of potential new therapeutic strategies. Here, we provide a detailed protocol that recapitulates some of the main histological and transcriptional features of human NEC in newborn mice.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages101-110
Number of pages10
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2321
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Enteric bacteria
  • Intestinal inflammation
  • Mucosal barrier
  • Necrotizing enterocolitis
  • Neonatal mice

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