A mouse model of flexor tendon repair

Sys Hasslund, Regis J. O'Keefe, Hani A. Awad

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Mouse models offer invaluable cellular and molecular tools for the study of human pathologies including those associated with fibrotic and musculoskeletal diseases. In this methods manuscript, we describe a mouse model of repair and segmental reconstruction of flexor tendons, which in our laboratory has been an invaluable model to study tendon scarring and adhesions. Specifically, we describe in details all the surgical procedures involved, as well as the associated endpoint biomechanical assessments including a novel test of the flexion of the metatarsophalangeal joint as a measure of adhesions, and a standard protocol for biomechanical assessment of the tensile strength of the tendon and repair tissue.

Original languageEnglish
Title of host publicationSkeletal Development and Repair
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages73-88
Number of pages16
ISBN (Print)9781627039888
DOIs
StatePublished - 2014
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1130
ISSN (Print)1064-3745

Keywords

  • Adhesions
  • Allograft
  • Autograft
  • Biomechanics
  • Flexor tendon
  • Repair
  • Tendoplasty

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    Hasslund, S., O'Keefe, R. J., & Awad, H. A. (2014). A mouse model of flexor tendon repair. In Skeletal Development and Repair: Methods and Protocols (pp. 73-88). (Methods in Molecular Biology; Vol. 1130). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-989-5_6