A mouse α-globin-related pseudogene lacking intervening sequences

Elio F. Vanin, Gregory I. Goldberg, Philip W. Tucker, Oliver Smithies

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

A mouse α-globin-related pseudogene (ψα30.5) completely lacks intervening sequences, and could not code for a functional globin polypeptide because of frameshifts. The widespread occurrence of globin pseudogenes in other species suggests that they are not 'dead' genes but may be important in controlling globin expression.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalNature
Volume286
Issue number5770
DOIs
StatePublished - Dec 1 1980
Externally publishedYes

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