A molecular understanding of alphavirus entry

Autumn C. Holmes, Katherine Basore, Daved H. Fremont, Michael S. Diamond

Research output: Contribution to journalReview articlepeer-review

Abstract

Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway, including attachment, internalization, and fusion. Herein, we review recent developments in the molecular understanding of alphavirus entry both in vitro and in vivo and how these advances might enable the design of therapeutics targeting this critical step in the alphavirus life cycle.

Original languageEnglish
Article numbere1008876
JournalPLoS pathogens
Volume16
Issue number10
DOIs
StatePublished - Oct 22 2020

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