A molecular bio-wire based multi-array biosensor with integrated potentiostat

Yang Liu, Amit Gore, Shantanu Chakrabartty, Evangelyn Alocilja

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

One of the important factors determining the sensitivity of any biosensing system is successful integration of bio-molecular transducers with peripheral signal processing circuitry. In this paper we present an architecture of a multi-array biosensor that integrates molecular bio-wires based immunosensor with a multi-channel potentiostat array. The biosensor operates by converting binding events between antigen and antibody into a measurable electrical signal using polyaniline nanowires as a transducer. The electrical signal is measured using a multichannel potentiostat where each channel comprises of a semi-synchronous ΣΔ modulator. Measured results using a fabricated potentiostat array demonstrate sensitivity down to 50 femtoam-pere range which makes it ideal for detecting pathogens at low concentration levels. Experiments using the biosensor array specific to Bacillus Cereus bacterium validate the functionality of the platform in detecting the pathogen at different concentration levels.

Original languageEnglish
Title of host publicationConference Proceedings - IEEE Biomedical Circuits and Systems Conference Healthcare Technology, BiOCAS2007
Pages29-32
Number of pages4
DOIs
StatePublished - 2007
EventIEEE Biomedical Circuits and Systems Conference Healthcare Technology, BiOCAS2007 - Montreal, QC, Canada
Duration: Nov 27 2007Nov 30 2007

Publication series

NameConference Proceedings - IEEE Biomedical Circuits and Systems Conference Healthcare Technology, BiOCAS2007

Conference

ConferenceIEEE Biomedical Circuits and Systems Conference Healthcare Technology, BiOCAS2007
Country/TerritoryCanada
CityMontreal, QC
Period11/27/0711/30/07

Keywords

  • Analog-to-digital converter
  • Biosensors
  • Femtoampere current measurements
  • Multi-channel converter
  • Potentiostat

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