TY - GEN
T1 - A molecular bio-wire based multi-array biosensor with integrated potentiostat
AU - Liu, Yang
AU - Gore, Amit
AU - Chakrabartty, Shantanu
AU - Alocilja, Evangelyn
PY - 2007
Y1 - 2007
N2 - One of the important factors determining the sensitivity of any biosensing system is successful integration of bio-molecular transducers with peripheral signal processing circuitry. In this paper we present an architecture of a multi-array biosensor that integrates molecular bio-wires based immunosensor with a multi-channel potentiostat array. The biosensor operates by converting binding events between antigen and antibody into a measurable electrical signal using polyaniline nanowires as a transducer. The electrical signal is measured using a multichannel potentiostat where each channel comprises of a semi-synchronous ΣΔ modulator. Measured results using a fabricated potentiostat array demonstrate sensitivity down to 50 femtoam-pere range which makes it ideal for detecting pathogens at low concentration levels. Experiments using the biosensor array specific to Bacillus Cereus bacterium validate the functionality of the platform in detecting the pathogen at different concentration levels.
AB - One of the important factors determining the sensitivity of any biosensing system is successful integration of bio-molecular transducers with peripheral signal processing circuitry. In this paper we present an architecture of a multi-array biosensor that integrates molecular bio-wires based immunosensor with a multi-channel potentiostat array. The biosensor operates by converting binding events between antigen and antibody into a measurable electrical signal using polyaniline nanowires as a transducer. The electrical signal is measured using a multichannel potentiostat where each channel comprises of a semi-synchronous ΣΔ modulator. Measured results using a fabricated potentiostat array demonstrate sensitivity down to 50 femtoam-pere range which makes it ideal for detecting pathogens at low concentration levels. Experiments using the biosensor array specific to Bacillus Cereus bacterium validate the functionality of the platform in detecting the pathogen at different concentration levels.
KW - Analog-to-digital converter
KW - Biosensors
KW - Femtoampere current measurements
KW - Multi-channel converter
KW - Potentiostat
UR - http://www.scopus.com/inward/record.url?scp=70350146454&partnerID=8YFLogxK
U2 - 10.1109/BIOCAS.2007.4463301
DO - 10.1109/BIOCAS.2007.4463301
M3 - Conference contribution
AN - SCOPUS:70350146454
SN - 142441525X
SN - 9781424415250
T3 - Conference Proceedings - IEEE Biomedical Circuits and Systems Conference Healthcare Technology, BiOCAS2007
SP - 29
EP - 32
BT - Conference Proceedings - IEEE Biomedical Circuits and Systems Conference Healthcare Technology, BiOCAS2007
T2 - IEEE Biomedical Circuits and Systems Conference Healthcare Technology, BiOCAS2007
Y2 - 27 November 2007 through 30 November 2007
ER -