@article{1206aa4008464f0aba23c8277d062b1c,
title = "A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes",
abstract = "Autoimmune diabetes is characterized by inflammatory infiltration; however, the initiating events are poorly understood. We found that the islets of Langerhans in young nonobese diabetic (NOD) mice contained two antigen-presenting cell (APC) populations: a major macrophage and a minor CD103+ dendritic cell (DC) population. By 4weeks of age, CD4+ Tcells entered islets coincident with an increase in CD103+ DCs. In order to examine the role of the CD103+ DCs in diabetes, we examined Batf3-deficient NOD mice that lacked the CD103+ DCs in islets and pancreatic lymph nodes. This led to a lack of autoreactive Tcells in islets and, importantly, no incidence of diabetes. Additional examination revealed that presentation of major histocompatibility complex (MHC) class I epitopes in the pancreatic lymph nodes was absent with a partial impairment of MHC class II presentation. Altogether, this study reveals that CD103+ DCs are essential for autoimmune diabetes development.",
author = "Ferris, {Stephen T.} and Carrero, {Javier A.} and Mohan, {James F.} and Boris Calderon and Murphy, {Kenneth M.} and Unanue, {Emil R.}",
note = "Funding Information: We thank all the members of our laboratory for many helpful discussions and assistance, and in particular Katherine E. Frederick, Xiaoxiao Wan, Lindsay Moore, and Anthony N. Vomund. This research was supported by the National Institutes of Health grants DK058177 and DK020579, Juvenile Diabetes Research Foundation (JDRF) 17-2012-141, and the Kilo Diabetes and Vascular Disease Foundation (Kilo). Experimental support was provided by the Rheumatic Diseases Core Center for Speed Congenics and by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR048335). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, JDRF, or the Kilo foundation. Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",
year = "2014",
month = oct,
day = "16",
doi = "10.1016/j.immuni.2014.09.012",
language = "English",
volume = "41",
pages = "657--669",
journal = "Immunity",
issn = "1074-7613",
number = "4",
}