A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development

Luisa Cervantes-Barragan; Marco Colonna

doi:10.1016/j.it.2022.09.012

A microbiota-derived antigen drives CD4⁺ intraepithelial lymphocyte (CD4IEL) development

Luisa Cervantes-Barragan
, Marco Colonna

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

CD4⁺ intraepithelial lymphocytes (CD4IEL) are tissue-resident T cells with cytotoxic and regulatory properties; together with peripheral regulatory T cells, they control intestinal inflammation. Recently, Bousbaine and colleagues identified a microbiota-derived conserved antigen that induces CD4IEL differentiation and promotes their regulatory function, attenuating the severity of murine colitis.

Original language	English
Pages (from-to)	858-860
Number of pages	3
Journal	Trends in Immunology
Volume	43
Issue number	11
DOIs	https://doi.org/10.1016/j.it.2022.09.012
State	Published - Nov 2022

Access to Document

10.1016/j.it.2022.09.012

Cite this

@article{93119663e7224494805a79fe340a3ed0,

title = "A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development",

abstract = "CD4+ intraepithelial lymphocytes (CD4IEL) are tissue-resident T cells with cytotoxic and regulatory properties; together with peripheral regulatory T cells, they control intestinal inflammation. Recently, Bousbaine and colleagues identified a microbiota-derived conserved antigen that induces CD4IEL differentiation and promotes their regulatory function, attenuating the severity of murine colitis.",

author = "Luisa Cervantes-Barragan and Marco Colonna",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = nov,

doi = "10.1016/j.it.2022.09.012",

language = "English",

volume = "43",

pages = "858--860",

journal = "Trends in Immunology",

issn = "1471-4906",

number = "11",

}

TY - JOUR

T1 - A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development

AU - Cervantes-Barragan, Luisa

AU - Colonna, Marco

PY - 2022/11

Y1 - 2022/11

N2 - CD4+ intraepithelial lymphocytes (CD4IEL) are tissue-resident T cells with cytotoxic and regulatory properties; together with peripheral regulatory T cells, they control intestinal inflammation. Recently, Bousbaine and colleagues identified a microbiota-derived conserved antigen that induces CD4IEL differentiation and promotes their regulatory function, attenuating the severity of murine colitis.

AB - CD4+ intraepithelial lymphocytes (CD4IEL) are tissue-resident T cells with cytotoxic and regulatory properties; together with peripheral regulatory T cells, they control intestinal inflammation. Recently, Bousbaine and colleagues identified a microbiota-derived conserved antigen that induces CD4IEL differentiation and promotes their regulatory function, attenuating the severity of murine colitis.

UR - https://www.scopus.com/pages/publications/85139736871

U2 - 10.1016/j.it.2022.09.012

DO - 10.1016/j.it.2022.09.012

M3 - Short survey

C2 - 36243620

AN - SCOPUS:85139736871

SN - 1471-4906

VL - 43

SP - 858

EP - 860

JO - Trends in Immunology

JF - Trends in Immunology

IS - 11

ER -

A microbiota-derived antigen drives CD4⁺ intraepithelial lymphocyte (CD4IEL) development

Abstract

Access to Document

Other files and links

Fingerprint

Cite this