TY - JOUR
T1 - A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development
AU - Cervantes-Barragan, Luisa
AU - Colonna, Marco
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/11
Y1 - 2022/11
N2 - CD4+ intraepithelial lymphocytes (CD4IEL) are tissue-resident T cells with cytotoxic and regulatory properties; together with peripheral regulatory T cells, they control intestinal inflammation. Recently, Bousbaine and colleagues identified a microbiota-derived conserved antigen that induces CD4IEL differentiation and promotes their regulatory function, attenuating the severity of murine colitis.
AB - CD4+ intraepithelial lymphocytes (CD4IEL) are tissue-resident T cells with cytotoxic and regulatory properties; together with peripheral regulatory T cells, they control intestinal inflammation. Recently, Bousbaine and colleagues identified a microbiota-derived conserved antigen that induces CD4IEL differentiation and promotes their regulatory function, attenuating the severity of murine colitis.
UR - http://www.scopus.com/inward/record.url?scp=85139736871&partnerID=8YFLogxK
U2 - 10.1016/j.it.2022.09.012
DO - 10.1016/j.it.2022.09.012
M3 - Short survey
C2 - 36243620
AN - SCOPUS:85139736871
SN - 1471-4906
VL - 43
SP - 858
EP - 860
JO - Trends in Immunology
JF - Trends in Immunology
IS - 11
ER -