A method to compute multiplicity corrected confidence intervals for odds ratios and other relative effect estimates

Jimmy Thomas Efird, Susan Searles Nielsen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Epidemiological studies commonly test multiple null hypotheses. In some situations it may be appropriate to account for multiplicity using statistical methodology rather than simply interpreting results with greater caution as the number of comparisons increases. Given the one-to-one relationship that exists between confidence intervals and hypothesis tests, we derive a method based upon the Hochberg step-up procedure to obtain multiplicity corrected confidence intervals (CI) for odds ratios (OR) and by analogy for other relative effect estimates. In contrast to previously published methods that explicitly assume knowledge of P values, this method only requires that relative effect estimates and corresponding CI be known for each comparison to obtain multiplicity corrected CI.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalInternational journal of environmental research and public health
Volume5
Issue number5
DOIs
StatePublished - Dec 2008

Keywords

  • Hochberg step-up procedure
  • Multiplicity correction

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