A method for the statistical evaluation of accurate mass measurement quality

Thomas M. Sack, Rick L. Lapp, Michael L. Gross, Brenda J. Kimble

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A generalized procedure for evaluating the accuracy and precision of mass measurements is described. A large, statistically significant number of mass spectra of a test compound, typically perfluorotributylamine, are acquired using a high resolution mass spectrometer. The mass measurement errors for a subset of the ionic fragments from the test compound are rigorously evaluated using statistical techniques. The results thus provided are a quantitative documentation of mass spectrometer performance. Experimental and theoretical statistical considerations are explored to refine the methodology into a general technique. Application of the method to the determination of the effects of various operating parameters such as choice of test compound, scan rate, magnet reset time, and peak intensity is demonstrated.

Original languageEnglish
Pages (from-to)191-210
Number of pages20
JournalInternational Journal of Mass Spectrometry and Ion Processes
Issue number2
StatePublished - Oct 8 1984


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