@article{4c81113e2f6e4ca7868182b40abc96a0,
title = "A method for simultaneous echo planar imaging of hyperpolarized 13C pyruvate and 13C lactate",
abstract = "A rapid echo planar imaging sequence for dynamic imaging of [1- 13C] lactate and [1- 13C] pyruvate simultaneously was developed. Frequency-based separation of these metabolites was achieved by spatial shifting in the phase-encoded direction with the appropriate choice of echo spacing. Suppression of the pyruvate-hydrate and alanine resonances is achieved through an optimized spectral-spatial RF waveform. Signal sampling efficiency as a function of pyruvate and lactate excitation angle was simulated using two site exchange models. Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed.",
keywords = "C13, EPI, Hyperpolarized, Kinetics, Pyruvate, Spectral spatial RF",
author = "Reed, \{Galen D.\} and Larson, \{Peder E.Z.\} and Morze, \{Cornelius Von\} and Robert Bok and Michael Lustig and Kerr, \{Adam B.\} and Pauly, \{John M.\} and John Kurhanewicz and Vigneron, \{Daniel B.\}",
note = "Funding Information: The authors thank Simon Hu, Christine Leon, Michael Ohliger, Kayvan Keshari, Subramaniam Sukumar, Douglas Kelley, Mark van Criekinge, and Bertram Koelsch for numerous helpful discussions, Hikari Yoshihara for substrate preparation, Kristen Scott for preparation of the animals used in this study, and Jim Tropp for the construction of the animal transmit/receive coil. The authors gratefully acknowledge funding from R01 EB007588, P41 EB013598, and UC Discovery Grant ITL-BIO04-10148 in conjunction with GE Healthcare. G.R. acknowledges funding from the ARCS foundation and offers particular thanks to Bruce and Betty Alberts, whose family serves as the role model for all of his scientific endeavors. ",
year = "2012",
month = apr,
doi = "10.1016/j.jmr.2012.02.008",
language = "English",
volume = "217",
pages = "41--47",
journal = "Journal of Magnetic Resonance",
issn = "1090-7807",
}