A method for simultaneous echo planar imaging of hyperpolarized 13C pyruvate and 13C lactate

Galen D. Reed, Peder E.Z. Larson, Cornelius Von Morze, Robert Bok, Michael Lustig, Adam B. Kerr, John M. Pauly, John Kurhanewicz, Daniel B. Vigneron

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A rapid echo planar imaging sequence for dynamic imaging of [1- 13C] lactate and [1- 13C] pyruvate simultaneously was developed. Frequency-based separation of these metabolites was achieved by spatial shifting in the phase-encoded direction with the appropriate choice of echo spacing. Suppression of the pyruvate-hydrate and alanine resonances is achieved through an optimized spectral-spatial RF waveform. Signal sampling efficiency as a function of pyruvate and lactate excitation angle was simulated using two site exchange models. Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalJournal of Magnetic Resonance
Volume217
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Keywords

  • C13
  • EPI
  • Hyperpolarized
  • Kinetics
  • Pyruvate
  • Spectral spatial RF

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    Reed, G. D., Larson, P. E. Z., Morze, C. V., Bok, R., Lustig, M., Kerr, A. B., Pauly, J. M., Kurhanewicz, J., & Vigneron, D. B. (2012). A method for simultaneous echo planar imaging of hyperpolarized 13C pyruvate and 13C lactate. Journal of Magnetic Resonance, 217, 41-47. https://doi.org/10.1016/j.jmr.2012.02.008