A method for reducing the effects of motion contamination in arterial spin labeling magnetic resonance imaging

Aaron B. Tanenbaum; Abraham Z. Snyder; Matthew R. Brier; Beau M. Ances

doi:10.1038/jcbfm.2015.124

A method for reducing the effects of motion contamination in arterial spin labeling magnetic resonance imaging

Aaron B. Tanenbaum, Abraham Z. Snyder, Matthew R. Brier, Beau M. Ances

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Arterial spin labeling (ASL) is a noninvasive method to measure cerebral blood flow (CBF). Arterial spin labeling is susceptible to artifact generated by head motion; this artifact is propagated through the subtraction procedure required to calculate CBF. We introduce a novel strategy for mitigating this artifact based on weighting tag/control volumes according to a noise estimate. We evaluated this strategy (DVARS weighting) in application to both pulsed ASL (PASL) and pseudo-continuous ASL (pCASL) in a cohort of normal adults (N=57). Application of DVARS weighting significantly improved test-retest repeatability as assessed by the intra-class correlation coefficient. Before the application of DVARS weighting, mean gray matter intra-class correlation (ICC) between subsequent ASL runs was 0.48 and 0.51 in PASL and pCASL, respectively. With weighting, ICC was significantly improved to 0.63 and 0.58.

Original language	English
Pages (from-to)	1697-1702
Number of pages	6
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	35
Issue number	10
DOIs	https://doi.org/10.1038/jcbfm.2015.124
State	Published - Oct 3 2015

Keywords

ASL
arterial spin labeling
cerebral blood flow measurement
perfusion-weighted MRI

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10.1038/jcbfm.2015.124

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title = "A method for reducing the effects of motion contamination in arterial spin labeling magnetic resonance imaging",

abstract = "Arterial spin labeling (ASL) is a noninvasive method to measure cerebral blood flow (CBF). Arterial spin labeling is susceptible to artifact generated by head motion; this artifact is propagated through the subtraction procedure required to calculate CBF. We introduce a novel strategy for mitigating this artifact based on weighting tag/control volumes according to a noise estimate. We evaluated this strategy (DVARS weighting) in application to both pulsed ASL (PASL) and pseudo-continuous ASL (pCASL) in a cohort of normal adults (N=57). Application of DVARS weighting significantly improved test-retest repeatability as assessed by the intra-class correlation coefficient. Before the application of DVARS weighting, mean gray matter intra-class correlation (ICC) between subsequent ASL runs was 0.48 and 0.51 in PASL and pCASL, respectively. With weighting, ICC was significantly improved to 0.63 and 0.58.",

keywords = "ASL, arterial spin labeling, cerebral blood flow measurement, perfusion-weighted MRI",

author = "Tanenbaum, {Aaron B.} and Snyder, {Abraham Z.} and Brier, {Matthew R.} and Ances, {Beau M.}",

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doi = "10.1038/jcbfm.2015.124",

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AU - Tanenbaum, Aaron B.

AU - Snyder, Abraham Z.

AU - Brier, Matthew R.

AU - Ances, Beau M.

PY - 2015/10/3

Y1 - 2015/10/3

N2 - Arterial spin labeling (ASL) is a noninvasive method to measure cerebral blood flow (CBF). Arterial spin labeling is susceptible to artifact generated by head motion; this artifact is propagated through the subtraction procedure required to calculate CBF. We introduce a novel strategy for mitigating this artifact based on weighting tag/control volumes according to a noise estimate. We evaluated this strategy (DVARS weighting) in application to both pulsed ASL (PASL) and pseudo-continuous ASL (pCASL) in a cohort of normal adults (N=57). Application of DVARS weighting significantly improved test-retest repeatability as assessed by the intra-class correlation coefficient. Before the application of DVARS weighting, mean gray matter intra-class correlation (ICC) between subsequent ASL runs was 0.48 and 0.51 in PASL and pCASL, respectively. With weighting, ICC was significantly improved to 0.63 and 0.58.

AB - Arterial spin labeling (ASL) is a noninvasive method to measure cerebral blood flow (CBF). Arterial spin labeling is susceptible to artifact generated by head motion; this artifact is propagated through the subtraction procedure required to calculate CBF. We introduce a novel strategy for mitigating this artifact based on weighting tag/control volumes according to a noise estimate. We evaluated this strategy (DVARS weighting) in application to both pulsed ASL (PASL) and pseudo-continuous ASL (pCASL) in a cohort of normal adults (N=57). Application of DVARS weighting significantly improved test-retest repeatability as assessed by the intra-class correlation coefficient. Before the application of DVARS weighting, mean gray matter intra-class correlation (ICC) between subsequent ASL runs was 0.48 and 0.51 in PASL and pCASL, respectively. With weighting, ICC was significantly improved to 0.63 and 0.58.

KW - ASL

KW - arterial spin labeling

KW - cerebral blood flow measurement

KW - perfusion-weighted MRI

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JO - Journal of Cerebral Blood Flow and Metabolism

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ER -

A method for reducing the effects of motion contamination in arterial spin labeling magnetic resonance imaging

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Keywords

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