Abstract
Mills and colleagues show that the common diabetes drug metformin activates the cellular energy hub AMP kinase (AMPK). AMPK slows mouse gastric stem cell proliferation, coaxing them to become acid-pumping parietal cells; it also promotes parietal cell mitochondria accumulation to power acid secretion. These results may explain the gastric side effects of metformin.
Original language | English |
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Pages (from-to) | 910-925.e6 |
Journal | Cell Stem Cell |
Volume | 26 |
Issue number | 6 |
DOIs | |
State | Published - Jun 4 2020 |
Keywords
- ADM
- SPEM
- mTORC1
- metaplasia
- mitochondria
- paligenosis
- ribosomes