A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation

Zhi Feng Miao; Mahliyah Adkins-Threats; Joseph R. Burclaff; Luciana H. Osaki; Jing Xu Sun; Yan Kefalov; Zheng He; Zhen Ning Wang; Jason C. Mills

doi:10.1016/j.stem.2020.03.006

A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation

Zhi Feng Miao, Mahliyah Adkins-Threats, Joseph R. Burclaff, Luciana H. Osaki, Jing Xu Sun, Yan Kefalov, Zheng He, Zhen Ning Wang, Jason C. Mills

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Mills and colleagues show that the common diabetes drug metformin activates the cellular energy hub AMP kinase (AMPK). AMPK slows mouse gastric stem cell proliferation, coaxing them to become acid-pumping parietal cells; it also promotes parietal cell mitochondria accumulation to power acid secretion. These results may explain the gastric side effects of metformin.

Original language	English
Pages (from-to)	910-925.e6
Journal	Cell Stem Cell
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2020.03.006
State	Published - Jun 4 2020

Keywords

ADM
SPEM
mTORC1
metaplasia
mitochondria
paligenosis
ribosomes

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abstract = "Mills and colleagues show that the common diabetes drug metformin activates the cellular energy hub AMP kinase (AMPK). AMPK slows mouse gastric stem cell proliferation, coaxing them to become acid-pumping parietal cells; it also promotes parietal cell mitochondria accumulation to power acid secretion. These results may explain the gastric side effects of metformin.",

keywords = "ADM, SPEM, mTORC1, metaplasia, mitochondria, paligenosis, ribosomes",

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A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation. / Miao, Zhi Feng; Adkins-Threats, Mahliyah; Burclaff, Joseph R.; Osaki, Luciana H.; Sun, Jing Xu; Kefalov, Yan; He, Zheng; Wang, Zhen Ning; Mills, Jason C.

In: Cell Stem Cell, Vol. 26, No. 6, 04.06.2020, p. 910-925.e6.

Research output: Contribution to journal › Article › peer-review

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