A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation

Zhi Feng Miao, Mahliyah Adkins-Threats, Joseph R. Burclaff, Luciana H. Osaki, Jing Xu Sun, Yan Kefalov, Zheng He, Zhen Ning Wang, Jason C. Mills

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Mills and colleagues show that the common diabetes drug metformin activates the cellular energy hub AMP kinase (AMPK). AMPK slows mouse gastric stem cell proliferation, coaxing them to become acid-pumping parietal cells; it also promotes parietal cell mitochondria accumulation to power acid secretion. These results may explain the gastric side effects of metformin.

Original languageEnglish
Pages (from-to)910-925.e6
JournalCell Stem Cell
Volume26
Issue number6
DOIs
StatePublished - Jun 4 2020

Keywords

  • ADM
  • SPEM
  • mTORC1
  • metaplasia
  • mitochondria
  • paligenosis
  • ribosomes

Fingerprint Dive into the research topics of 'A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation'. Together they form a unique fingerprint.

Cite this