A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program

Michael A. Province; Sharon L.R. Kardia; Koustubh Ranade; Dabeeru C. Rao; Bonnie A. Thiel; Richard S. Cooper; Neil Risch; Stephen T. Turner; David R. Cox; Steven C. Hunt; Alan B. Weder; Eric Boerwinkle

doi:10.1016/S0895-7061(02)03248-X

A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program

Michael A. Province, Sharon L.R. Kardia, Koustubh Ranade, Dabeeru C. Rao, Bonnie A. Thiel, Richard S. Cooper, Neil Risch, Stephen T. Turner, David R. Cox, Steven C. Hunt, Alan B. Weder, Eric Boerwinkle

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100 Scopus citations

Abstract

Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives). Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage. Conclusions: No regions show uniformly large effects on BP/hypertension in all populations.

Original language	English
Pages (from-to)	144-147
Number of pages	4
Journal	American Journal of Hypertension
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/S0895-7061(02)03248-X
State	Published - Feb 1 2003

Keywords

Genome scan
Hypertension
Meta-analysis

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Province, M. A., Kardia, S. L. R., Ranade, K., Rao, D. C., Thiel, B. A., Cooper, R. S., Risch, N., Turner, S. T., Cox, D. R., Hunt, S. C., Weder, A. B., & Boerwinkle, E. (2003). A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program. American Journal of Hypertension, 16(2), 144-147. https://doi.org/10.1016/S0895-7061(02)03248-X

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title = "A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program",

abstract = "Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives). Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage. Conclusions: No regions show uniformly large effects on BP/hypertension in all populations.",

keywords = "Genome scan, Hypertension, Meta-analysis",

author = "Province, {Michael A.} and Kardia, {Sharon L.R.} and Koustubh Ranade and Rao, {Dabeeru C.} and Thiel, {Bonnie A.} and Cooper, {Richard S.} and Neil Risch and Turner, {Stephen T.} and Cox, {David R.} and Hunt, {Steven C.} and Weder, {Alan B.} and Eric Boerwinkle",

note = "Funding Information: The entire Family Blood Pressure Program is supported by a series of cooperative agreements (U01) with the National Heart, Lung and Blood Institute. GenNet: HL45508 and HL47910; GENOA: R01 HL51021 and U10 HL54481, HL54464; HyperGEN: HL54473, HL54496, HL54472, HL54515, HL54495, HL54497, HL54471, and HL54509; SAPPHIRe: 2HHZ598. ",

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doi = "10.1016/S0895-7061(02)03248-X",

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Province, MA, Kardia, SLR, Ranade, K, Rao, DC, Thiel, BA, Cooper, RS, Risch, N, Turner, ST, Cox, DR, Hunt, SC, Weder, AB & Boerwinkle, E 2003, 'A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program', American Journal of Hypertension, vol. 16, no. 2, pp. 144-147. https://doi.org/10.1016/S0895-7061(02)03248-X

TY - JOUR

T1 - A meta-analysis of genome-wide linkage scans for hypertension

T2 - The National Heart, Lung and Blood Institute Family Blood Pressure Program

AU - Province, Michael A.

AU - Kardia, Sharon L.R.

AU - Ranade, Koustubh

AU - Rao, Dabeeru C.

AU - Thiel, Bonnie A.

AU - Cooper, Richard S.

AU - Risch, Neil

AU - Turner, Stephen T.

AU - Cox, David R.

AU - Hunt, Steven C.

AU - Weder, Alan B.

AU - Boerwinkle, Eric

N1 - Funding Information: The entire Family Blood Pressure Program is supported by a series of cooperative agreements (U01) with the National Heart, Lung and Blood Institute. GenNet: HL45508 and HL47910; GENOA: R01 HL51021 and U10 HL54481, HL54464; HyperGEN: HL54473, HL54496, HL54472, HL54515, HL54495, HL54497, HL54471, and HL54509; SAPPHIRe: 2HHZ598.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives). Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage. Conclusions: No regions show uniformly large effects on BP/hypertension in all populations.

AB - Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives). Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage. Conclusions: No regions show uniformly large effects on BP/hypertension in all populations.

KW - Genome scan

KW - Hypertension

KW - Meta-analysis

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SN - 0895-7061

VL - 16

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JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 2

ER -

A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program

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Keywords

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