A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis

Dottington Fullwood; Rebecca N. Gomez; Zhiguang Huo; Josue S. Cardoso; Emily J. Bartley; Staja Q. Booker; Keesha L. Powell-Roach; Alisa J. Johnson; Kimberly T. Sibille; Adriana S. Addison; Burel R. Goodin; Roland Staud; David T. Redden; Roger B. Fillingim; Ellen L. Terry

doi:10.1016/j.jpain.2021.04.018

A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis

Dottington Fullwood, Rebecca N. Gomez, Zhiguang Huo, Josue S. Cardoso, Emily J. Bartley, Staja Q. Booker, Keesha L. Powell-Roach, Alisa J. Johnson, Kimberly T. Sibille, Adriana S. Addison, Burel R. Goodin, Roland Staud, David T. Redden, Roger B. Fillingim, Ellen L. Terry

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20 Scopus citations

Abstract

The current cross-sectional study investigates whether pain catastrophizing mediates the relationship between ethnicity/race and pain, disability and physical function in individuals with knee osteoarthritis. Furthermore, this study examined mediation at 2-year follow-up. Participants included 187 community-dwelling adults with unilateral or bilateral knee pain who screened positive for knee osteoarthritis. Participants completed several self-reported pain-related measures and pain catastrophizing subscale at baseline and 2-year follow-up. Non-Hispanic Black (NHB) adults reported greater pain, disability, and poorer functional performance compared to their non-Hispanic White (NHW) counterparts (Ps < .05). NHB adults also reported greater catastrophizing compared to NHW adults. Mediation analyses revealed that catastrophizing mediated the relationship between ethnicity/race and pain outcome measures. Specifically, NHB individuals reported significantly greater pain and disability, and exhibited lower levels of physical function, compared to NHW individuals, and these differences were mediated by higher levels of catastrophizing among NHB persons. Catastrophizing was a significant predictor of pain and disability 2-years later in both ethnic/race groups. These results suggest that pain catastrophizing is an important variable to consider in efforts to reduce ethnic/race group disparities in chronic pain. The findings are discussed in light of structural/systemic factors that may contribute to greater self-reports of pain catastrophizing among NHB individuals. Perspective: The current study examines whether pain catastrophizing mediates the relationship between ethnicity/race and OA-related pain, disability, and functional impairment at baseline and during a 2-year follow-up period in non-Hispanic Black and non-Hispanic White adults with knee pain. These results point to the need for interventions that target pain catastrophizing.

Original language	English
Pages (from-to)	1452-1466
Number of pages	15
Journal	Journal of Pain
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.jpain.2021.04.018
State	Published - Nov 2021

Keywords

Pain catastrophizing
chronic pain
disability
ethnicity/race
knee osteoarthritis

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10.1016/j.jpain.2021.04.018

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Fullwood, D., Gomez, R. N., Huo, Z., Cardoso, J. S., Bartley, E. J., Booker, S. Q., Powell-Roach, K. L., Johnson, A. J., Sibille, K. T., Addison, A. S., Goodin, B. R., Staud, R., Redden, D. T., Fillingim, R. B., & Terry, E. L. (2021). A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis. Journal of Pain, 22(11), 1452-1466. https://doi.org/10.1016/j.jpain.2021.04.018

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title = "A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis",

abstract = "The current cross-sectional study investigates whether pain catastrophizing mediates the relationship between ethnicity/race and pain, disability and physical function in individuals with knee osteoarthritis. Furthermore, this study examined mediation at 2-year follow-up. Participants included 187 community-dwelling adults with unilateral or bilateral knee pain who screened positive for knee osteoarthritis. Participants completed several self-reported pain-related measures and pain catastrophizing subscale at baseline and 2-year follow-up. Non-Hispanic Black (NHB) adults reported greater pain, disability, and poorer functional performance compared to their non-Hispanic White (NHW) counterparts (Ps < .05). NHB adults also reported greater catastrophizing compared to NHW adults. Mediation analyses revealed that catastrophizing mediated the relationship between ethnicity/race and pain outcome measures. Specifically, NHB individuals reported significantly greater pain and disability, and exhibited lower levels of physical function, compared to NHW individuals, and these differences were mediated by higher levels of catastrophizing among NHB persons. Catastrophizing was a significant predictor of pain and disability 2-years later in both ethnic/race groups. These results suggest that pain catastrophizing is an important variable to consider in efforts to reduce ethnic/race group disparities in chronic pain. The findings are discussed in light of structural/systemic factors that may contribute to greater self-reports of pain catastrophizing among NHB individuals. Perspective: The current study examines whether pain catastrophizing mediates the relationship between ethnicity/race and OA-related pain, disability, and functional impairment at baseline and during a 2-year follow-up period in non-Hispanic Black and non-Hispanic White adults with knee pain. These results point to the need for interventions that target pain catastrophizing.",

keywords = "Pain catastrophizing, chronic pain, disability, ethnicity/race, knee osteoarthritis",

author = "Dottington Fullwood and Gomez, {Rebecca N.} and Zhiguang Huo and Cardoso, {Josue S.} and Bartley, {Emily J.} and Booker, {Staja Q.} and Powell-Roach, {Keesha L.} and Johnson, {Alisa J.} and Sibille, {Kimberly T.} and Addison, {Adriana S.} and Goodin, {Burel R.} and Roland Staud and Redden, {David T.} and Fillingim, {Roger B.} and Terry, {Ellen L.}",

note = "Publisher Copyright: {\textcopyright} 2021 United States Association for the Study of Pain, Inc.",

year = "2021",

month = nov,

doi = "10.1016/j.jpain.2021.04.018",

language = "English",

volume = "22",

pages = "1452--1466",

journal = "Journal of Pain",

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Fullwood, D, Gomez, RN, Huo, Z, Cardoso, JS, Bartley, EJ, Booker, SQ, Powell-Roach, KL, Johnson, AJ, Sibille, KT, Addison, AS, Goodin, BR, Staud, R, Redden, DT, Fillingim, RB & Terry, EL 2021, 'A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis', Journal of Pain, vol. 22, no. 11, pp. 1452-1466. https://doi.org/10.1016/j.jpain.2021.04.018

TY - JOUR

T1 - A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis

AU - Fullwood, Dottington

AU - Gomez, Rebecca N.

AU - Huo, Zhiguang

AU - Cardoso, Josue S.

AU - Bartley, Emily J.

AU - Booker, Staja Q.

AU - Powell-Roach, Keesha L.

AU - Johnson, Alisa J.

AU - Sibille, Kimberly T.

AU - Addison, Adriana S.

AU - Goodin, Burel R.

AU - Staud, Roland

AU - Redden, David T.

AU - Fillingim, Roger B.

AU - Terry, Ellen L.

PY - 2021/11

Y1 - 2021/11

N2 - The current cross-sectional study investigates whether pain catastrophizing mediates the relationship between ethnicity/race and pain, disability and physical function in individuals with knee osteoarthritis. Furthermore, this study examined mediation at 2-year follow-up. Participants included 187 community-dwelling adults with unilateral or bilateral knee pain who screened positive for knee osteoarthritis. Participants completed several self-reported pain-related measures and pain catastrophizing subscale at baseline and 2-year follow-up. Non-Hispanic Black (NHB) adults reported greater pain, disability, and poorer functional performance compared to their non-Hispanic White (NHW) counterparts (Ps < .05). NHB adults also reported greater catastrophizing compared to NHW adults. Mediation analyses revealed that catastrophizing mediated the relationship between ethnicity/race and pain outcome measures. Specifically, NHB individuals reported significantly greater pain and disability, and exhibited lower levels of physical function, compared to NHW individuals, and these differences were mediated by higher levels of catastrophizing among NHB persons. Catastrophizing was a significant predictor of pain and disability 2-years later in both ethnic/race groups. These results suggest that pain catastrophizing is an important variable to consider in efforts to reduce ethnic/race group disparities in chronic pain. The findings are discussed in light of structural/systemic factors that may contribute to greater self-reports of pain catastrophizing among NHB individuals. Perspective: The current study examines whether pain catastrophizing mediates the relationship between ethnicity/race and OA-related pain, disability, and functional impairment at baseline and during a 2-year follow-up period in non-Hispanic Black and non-Hispanic White adults with knee pain. These results point to the need for interventions that target pain catastrophizing.

AB - The current cross-sectional study investigates whether pain catastrophizing mediates the relationship between ethnicity/race and pain, disability and physical function in individuals with knee osteoarthritis. Furthermore, this study examined mediation at 2-year follow-up. Participants included 187 community-dwelling adults with unilateral or bilateral knee pain who screened positive for knee osteoarthritis. Participants completed several self-reported pain-related measures and pain catastrophizing subscale at baseline and 2-year follow-up. Non-Hispanic Black (NHB) adults reported greater pain, disability, and poorer functional performance compared to their non-Hispanic White (NHW) counterparts (Ps < .05). NHB adults also reported greater catastrophizing compared to NHW adults. Mediation analyses revealed that catastrophizing mediated the relationship between ethnicity/race and pain outcome measures. Specifically, NHB individuals reported significantly greater pain and disability, and exhibited lower levels of physical function, compared to NHW individuals, and these differences were mediated by higher levels of catastrophizing among NHB persons. Catastrophizing was a significant predictor of pain and disability 2-years later in both ethnic/race groups. These results suggest that pain catastrophizing is an important variable to consider in efforts to reduce ethnic/race group disparities in chronic pain. The findings are discussed in light of structural/systemic factors that may contribute to greater self-reports of pain catastrophizing among NHB individuals. Perspective: The current study examines whether pain catastrophizing mediates the relationship between ethnicity/race and OA-related pain, disability, and functional impairment at baseline and during a 2-year follow-up period in non-Hispanic Black and non-Hispanic White adults with knee pain. These results point to the need for interventions that target pain catastrophizing.

KW - Pain catastrophizing

KW - chronic pain

KW - disability

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A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis

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Keywords

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