Abstract
Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical may be important in the modulation of prostacyclin synthesis in disease states.
| Original language | English |
|---|---|
| Pages (from-to) | 1191-1196 |
| Number of pages | 6 |
| Journal | Blood |
| Volume | 53 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1979 |