A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase

S. J. Weiss, J. Turk, P. Needleman

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical may be important in the modulation of prostacyclin synthesis in disease states.

Original languageEnglish
Pages (from-to)1191-1196
Number of pages6
JournalBlood
Volume53
Issue number6
DOIs
StatePublished - 1979

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