A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions

Keyphrases

• APOE Gene 20%
• ApoE3 80%
• APOE4 100%
• Apolipoprotein E 100%
• Arginine 20%
• Binding Specificity 20%
• Cysteine 20%
• Domain-domain Interaction 100%
• Hydrogen-deuterium Exchange Mass Spectrometry 20%
• Intrinsically Disordered Region 100%
• Late-onset Alzheimer's Disease 20%
• Lipid Binding 100%
• Lipids 40%
• Mass Spectrometry Data 20%
• Protein Motion 20%
• Region Control 20%
• Single Amino Acid 20%
• Two-component Domains 20%

Biochemistry, Genetics and Molecular Biology

• Allele 20%
• Amino Acids 20%
• Apolipoprotein E 100%
• Arginine 20%
• C-Terminus 20%
• Cysteine 20%
• Eicosanoid Receptor 20%
• Hydrogen/Deuterium Exchange Mass Spectrometry 20%
• Isoform 20%
• Lipid 100%
• Motion 20%
• N-Terminus 20%