A low dose of aripiprazole attenuates the subject-rated effects of d-amphetamine

William W. Stoops, Joshua A. Lile, Paul E.A. Glaser, Craig R. Rush

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Despite increased reports of amphetamine abuse and dependence, a putative pharmacotherapy has yet to be identified. In a previous study from our laboratory, 20 mg aripiprazole, an atypical antipsychotic that has partial agonist activity at D2 receptors, attenuated many of the behavioral effects of d-amphetamine. Aripiprazole (20 mg) also impaired performance on a computerized version of the DSST when administered alone, indicating that the attenuation observed may have been functional as opposed to receptor mediated. The present experiment was conducted to determine whether a lower dose of aripiprazole (10 mg) could acutely attenuate the discriminative-stimulus, subject-rated, and physiological effects of d-amphetamine (2.5-15 mg) without impairing performance as measured with a computerized version of the DSST. The results of the present experiment indicate that 10 mg aripiprazole attenuated some abuse-related behavioral effects of d-amphetamine and was generally devoid of effects, including significant performance impairment, when administered alone. These findings suggest that 10 mg aripiprazole would be a reasonable starting dose for the treatment of stimulant abuse and dependence. Future research should examine the effects of chronic aripiprazole administration in combination with methamphetamine or cocaine.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalDrug and Alcohol Dependence
Volume84
Issue number2
DOIs
StatePublished - Sep 15 2006

Keywords

  • Aripiprazole
  • Drug discrimination
  • Partial agonist
  • Subject-rated effects
  • d-Amphetamine

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