A little stress is good: IFN-γ, demyelination, and multiple sclerosis

Jason R. Lees, Anne H. Cross

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


The exact role(s) of the cytokine IFN-γ in the demyelinating disease multiple sclerosis remain controversial, with evidence suggesting both detrimental and protective effects of the cytokine in MS and MS models such as EAE. The study by Lin and coworkers in this issue of the JCI produces evidence that protective effects of IFN-γ on mature oligodendrocytes during EAE induction are mediated via activation of the pancreatic ER kinase (PERK), resulting in induction of the endoplasmic reticular stress response pathway (see the related article beginning on page 448). Modulation of this stress pathway has what we believe to be novel therapeutic potential for MS.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalJournal of Clinical Investigation
Issue number2
StatePublished - Feb 1 2007


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