TY - JOUR
T1 - A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord
AU - Meacham, Kathleen W.
AU - Giuly, Richard J.
AU - Guo, Liang
AU - Hochman, Shawn
AU - DeWeerth, Stephen P.
N1 - Funding Information:
Acknowledgements We thank James Ross for discussions regarding fabrication strategies, Bao To for machining and assembling initial versions of the clamping connector., J.Mark Meacham for illustration software help, and Jevin Scrivens, Edgar Brown, and Shane Migliore for advice about building and using the strain tester. This work was supported by NIH Grant EB00786-01, NSF IBN-0349042, and NIH Grant EB006179.
PY - 2008/4
Y1 - 2008/4
N2 - A new, scalable process for microfabrication of a silicone-based, elastic multi-electrode array (MEA) is presented. The device is constructed by spinning poly(dimethylsiloxane) (PDMS) silicone elastomer onto a glass slide, depositing and patterning gold to construct wires and electrodes, spinning on a second PDMS layer, and then micropatterning the second PDMS layer to expose electrode contacts. The micropatterning of PDMS involves a custom reactive ion etch (RIE) process that preserves the underlying gold thin film. Once completed, the device can be removed from the glass slide for conformal interfacing with neural tissue. Prototype MEAs feature electrodes smaller than those known to be reported on silicone substrate (60 μm diameter exposed electrode area) and were capable of selectively stimulating the surface of the in vitro isolated spinal cord of the juvenile rat. Stretchable serpentine traces were also incorporated into the functional PDMS-based MEA, and their implementation and testing is described.
AB - A new, scalable process for microfabrication of a silicone-based, elastic multi-electrode array (MEA) is presented. The device is constructed by spinning poly(dimethylsiloxane) (PDMS) silicone elastomer onto a glass slide, depositing and patterning gold to construct wires and electrodes, spinning on a second PDMS layer, and then micropatterning the second PDMS layer to expose electrode contacts. The micropatterning of PDMS involves a custom reactive ion etch (RIE) process that preserves the underlying gold thin film. Once completed, the device can be removed from the glass slide for conformal interfacing with neural tissue. Prototype MEAs feature electrodes smaller than those known to be reported on silicone substrate (60 μm diameter exposed electrode area) and were capable of selectively stimulating the surface of the in vitro isolated spinal cord of the juvenile rat. Stretchable serpentine traces were also incorporated into the functional PDMS-based MEA, and their implementation and testing is described.
KW - Electrophysiology
KW - Multi-electrode array
KW - Neural control
KW - Neural interfacing
KW - Neural prosthetic
KW - Poly(dimethylsiloxane)
KW - Spinal cord
KW - Spinal cord injury
KW - Surface stimulation
UR - http://www.scopus.com/inward/record.url?scp=40449089502&partnerID=8YFLogxK
U2 - 10.1007/s10544-007-9132-9
DO - 10.1007/s10544-007-9132-9
M3 - Article
C2 - 17914674
AN - SCOPUS:40449089502
SN - 1387-2176
VL - 10
SP - 259
EP - 269
JO - Biomedical Microdevices
JF - Biomedical Microdevices
IS - 2
ER -