A List-Mode OSEM-Based Attenuation and Scatter Compensation Method for SPECT

Md Ashequr Rahman, Richard Laforest, Abhinav K. Jha

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Reliable attenuation and scatter compensation (ASC) is a pre-requisite for quantification and beneficial for visual interpretation tasks in SPECT. In this paper, we develop a reconstruction method that uses the entire SPECT emission data, i.e. data in both the photopeak and scatter windows, acquired in list-mode format and including the energy attribute of the detected photon, to perform ASC. We implemented a GPU-based version of this method using an ordered subsets expectation maximization (OSEM) algorithm. The method was objectively evaluated using realistic simulation studies on the task of estimating uptake in the striatal regions of the brain in a 2-D dopamine transporter (DaT)-scan SPECT study. We observed that inclusion of data from the scatter window and using list-mode data yielded improved quantification compared to using data only from the photopeak window or using binned data. These results motivate further development of list-mode-based ASC methods that include scatter-window data for SPECT.

Original languageEnglish
Title of host publicationISBI 2020 - 2020 IEEE International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages646-650
Number of pages5
ISBN (Electronic)9781538693308
DOIs
StatePublished - Apr 2020
Event17th IEEE International Symposium on Biomedical Imaging, ISBI 2020 - Iowa City, United States
Duration: Apr 3 2020Apr 7 2020

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2020-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference17th IEEE International Symposium on Biomedical Imaging, ISBI 2020
CountryUnited States
CityIowa City
Period04/3/2004/7/20

Keywords

  • Attenuation and scatter compensation
  • Brain
  • List-mode data
  • Parkinson's disease
  • Reconstruction
  • SPECT

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    Rahman, M. A., Laforest, R., & Jha, A. K. (2020). A List-Mode OSEM-Based Attenuation and Scatter Compensation Method for SPECT. In ISBI 2020 - 2020 IEEE International Symposium on Biomedical Imaging (pp. 646-650). [9098333] (Proceedings - International Symposium on Biomedical Imaging; Vol. 2020-April). IEEE Computer Society. https://doi.org/10.1109/ISBI45749.2020.9098333