Abstract
The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically. We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2-3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.
Original language | English |
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Pages (from-to) | 1619-1623 |
Number of pages | 5 |
Journal | Epilepsia |
Volume | 51 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2010 |
Keywords
- Calorie-restricted
- Conditioned fear test
- Locomotor activity
- Medial perforant path
- Paired-pulse modulation