A ketogenic diet does not impair rat behavior or long-term potentiation: BRIEF COMMUNICATION

Liu Lin Thio, Nicholas Rensing, Susan Maloney, David F. Wozniak, Chengjie Xiong, Kelvin A. Yamada

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically. We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2-3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.

Original languageEnglish
Pages (from-to)1619-1623
Number of pages5
JournalEpilepsia
Volume51
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • Calorie-restricted
  • Conditioned fear test
  • Locomotor activity
  • Medial perforant path
  • Paired-pulse modulation

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