A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes

Paul H. Schlesinger; Riccardo Ferdani; Robert Pajewski; Jolanta Pajewska; George W. Gokel

doi:10.1039/b200126h

A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes

Paul H. Schlesinger, Riccardo Ferdani, Robert Pajewski, Jolanta Pajewska, George W. Gokel

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41 Scopus citations

Abstract

The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C₁₈H₃₇)₂NCOCH₂OCH₂COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.

Original language	English
Pages (from-to)	840-841
Number of pages	2
Journal	Chemical Communications
Volume	2
Issue number	8
DOIs	https://doi.org/10.1039/b200126h
State	Published - Jan 1 2002

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title = "A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes",

abstract = "The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.",

author = "Schlesinger, {Paul H.} and Riccardo Ferdani and Robert Pajewski and Jolanta Pajewska and Gokel, {George W.}",

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AU - Schlesinger, Paul H.

AU - Ferdani, Riccardo

AU - Pajewski, Robert

AU - Pajewska, Jolanta

AU - Gokel, George W.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.

AB - The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.

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DO - 10.1039/b200126h

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A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes

Abstract

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