A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes

Paul H. Schlesinger, Riccardo Ferdani, Robert Pajewski, Jolanta Pajewska, George W. Gokel

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.

Original languageEnglish
Pages (from-to)840-841
Number of pages2
JournalChemical Communications
Volume2
Issue number8
DOIs
StatePublished - Jan 1 2002

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