A hybrid positron detection and optical coherence tomography system: Design, calibration and experimental validation with rabbit atherosclerotic models

Quing Zhu; Daqing Piao; Mehran M. Sadeghi; Jiasheng Zhang; Yueli Chen; Albert J. Sinusas

doi:10.1117/12.592603

A hybrid positron detection and optical coherence tomography system: Design, calibration and experimental validation with rabbit atherosclerotic models

Quing Zhu
, Daqing Piao
, Mehran M. Sadeghi
, Jiasheng Zhang
, Yueli Chen
, Albert J. Sinusas

Department of Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

In this paper, we evaluate the performance of our novel hybrid OCT and scintillating probe, demonstrate simultaneous optical coherence tomography (OCT) imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of Fluorodeoxyglucose (FDG) labeled with ¹⁸F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that co-registered high-resolution OCT images provide imaging of detailed plaque microstructure, which cannot be resolved by positron detection.

Original language	English
Article number	60
Pages (from-to)	356-364
Number of pages	9
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5690
DOIs	https://doi.org/10.1117/12.592603
State	Published - 2005
Event	Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States Duration: Jan 23 2005 → Jan 26 2005

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@article{feacef79b3124674812b4854cc55e650,

title = "A hybrid positron detection and optical coherence tomography system: Design, calibration and experimental validation with rabbit atherosclerotic models",

abstract = "In this paper, we evaluate the performance of our novel hybrid OCT and scintillating probe, demonstrate simultaneous optical coherence tomography (OCT) imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of Fluorodeoxyglucose (FDG) labeled with 18F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that co-registered high-resolution OCT images provide imaging of detailed plaque microstructure, which cannot be resolved by positron detection.",

author = "Quing Zhu and Daqing Piao and Sadeghi, \{Mehran M.\} and Jiasheng Zhang and Yueli Chen and Sinusas, \{Albert J.\}",

year = "2005",

doi = "10.1117/12.592603",

language = "English",

volume = "5690",

pages = "356--364",

journal = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

issn = "1605-7422",

note = "Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX ; Conference date: 23-01-2005 Through 26-01-2005",

}

A hybrid positron detection and optical coherence tomography system: Design, calibration and experimental validation with rabbit atherosclerotic models. / Zhu, Quing; Piao, Daqing; Sadeghi, Mehran M. et al.
In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 5690, 60, 2005, p. 356-364.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - A hybrid positron detection and optical coherence tomography system

T2 - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX

AU - Zhu, Quing

AU - Piao, Daqing

AU - Sadeghi, Mehran M.

AU - Zhang, Jiasheng

AU - Chen, Yueli

AU - Sinusas, Albert J.

PY - 2005

Y1 - 2005

N2 - In this paper, we evaluate the performance of our novel hybrid OCT and scintillating probe, demonstrate simultaneous optical coherence tomography (OCT) imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of Fluorodeoxyglucose (FDG) labeled with 18F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that co-registered high-resolution OCT images provide imaging of detailed plaque microstructure, which cannot be resolved by positron detection.

AB - In this paper, we evaluate the performance of our novel hybrid OCT and scintillating probe, demonstrate simultaneous optical coherence tomography (OCT) imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of Fluorodeoxyglucose (FDG) labeled with 18F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that co-registered high-resolution OCT images provide imaging of detailed plaque microstructure, which cannot be resolved by positron detection.

UR - https://www.scopus.com/pages/publications/21844445537

U2 - 10.1117/12.592603

DO - 10.1117/12.592603

M3 - Conference article

AN - SCOPUS:21844445537

SN - 1605-7422

VL - 5690

SP - 356

EP - 364

JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

M1 - 60

Y2 - 23 January 2005 through 26 January 2005

ER -

A hybrid positron detection and optical coherence tomography system: Design, calibration and experimental validation with rabbit atherosclerotic models

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