A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization

Yi Yang; Nrusingh C. Biswal; Tianheng Wang; Patrick Kumavor; Mozafareddin Karimeddini; Melinda Sanders; Molly Brewer; Quing Zhu

doi:10.1117/12.878860

A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization

Yi Yang
, Nrusingh C. Biswal
, Tianheng Wang
, Patrick Kumavor
, Mozafareddin Karimeddini
, Melinda Sanders
, Molly Brewer
, Quing Zhu

Department of Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Ovarian cancer has the lowest survival rate of the gynecologic cancers with a 5-year survival of about 50% in the United States. With current screening and diagnostic abilities for ovarian cancers, most of the diagnosed patients are already with advanced stages and the majority of them will die of this deadly disease. In this paper, we report a multimodal imaging approach which combines optical coherence tomography (OCT) and positron detection for early ovarian cancer detection. The dual modality system has the capability of providing both functional and morphological images simultaneously. While the positron detection provides the metabolism activity of the ovary due to the uptake of radiotracer, the OCT provides the high resolution (25μm X 25μm X 12μm - longitudinal X lateral X axial in air) structural imaging at 20k A-lines per second. Total 18 ovaries obtained from 10 patients classified as normal, abnormal and malignant ovarian tissues were characterized ex vivo. Positron counts of 1.2-fold higher was found between abnormal and normal ovaries and 3~30-fold higher was found between malignant and normal ovaries. OCT imaging of malignant and abnormal ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in the ovary.

Original language	English
Title of host publication	Multimodal Biomedical Imaging VI
DOIs	https://doi.org/10.1117/12.878860
State	Published - 2011
Event	Multimodal Biomedical Imaging VI - San Francisco, CA, United States Duration: Jan 22 2011 → Jan 23 2011

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7892
ISSN (Print)	1605-7422

Conference

Conference	Multimodal Biomedical Imaging VI
Country/Territory	United States
City	San Francisco, CA
Period	01/22/11 → 01/23/11

Keywords

gynecology
intraoperative probe
optical coherence tomography
ovarian cancer
positron detection

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10.1117/12.878860

Cite this

@inproceedings{95051b4d69f748dc9487f91427d528c6,

title = "A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization",

abstract = "Ovarian cancer has the lowest survival rate of the gynecologic cancers with a 5-year survival of about 50\% in the United States. With current screening and diagnostic abilities for ovarian cancers, most of the diagnosed patients are already with advanced stages and the majority of them will die of this deadly disease. In this paper, we report a multimodal imaging approach which combines optical coherence tomography (OCT) and positron detection for early ovarian cancer detection. The dual modality system has the capability of providing both functional and morphological images simultaneously. While the positron detection provides the metabolism activity of the ovary due to the uptake of radiotracer, the OCT provides the high resolution (25μm X 25μm X 12μm - longitudinal X lateral X axial in air) structural imaging at 20k A-lines per second. Total 18 ovaries obtained from 10 patients classified as normal, abnormal and malignant ovarian tissues were characterized ex vivo. Positron counts of 1.2-fold higher was found between abnormal and normal ovaries and 3\textasciitilde{}30-fold higher was found between malignant and normal ovaries. OCT imaging of malignant and abnormal ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in the ovary.",

keywords = "gynecology, intraoperative probe, optical coherence tomography, ovarian cancer, positron detection",

author = "Yi Yang and Biswal, \{Nrusingh C.\} and Tianheng Wang and Patrick Kumavor and Mozafareddin Karimeddini and Melinda Sanders and Molly Brewer and Quing Zhu",

year = "2011",

doi = "10.1117/12.878860",

language = "English",

isbn = "9780819484291",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Multimodal Biomedical Imaging VI",

note = "Multimodal Biomedical Imaging VI ; Conference date: 22-01-2011 Through 23-01-2011",

}

Yang, Y, Biswal, NC, Wang, T, Kumavor, P, Karimeddini, M, Sanders, M, Brewer, M & Zhu, Q 2011, A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization. in Multimodal Biomedical Imaging VI., 78920Y, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7892, Multimodal Biomedical Imaging VI, San Francisco, CA, United States, 01/22/11. https://doi.org/10.1117/12.878860

A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization. / Yang, Yi; Biswal, Nrusingh C.; Wang, Tianheng et al.
Multimodal Biomedical Imaging VI. 2011. 78920Y (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7892).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization

AU - Yang, Yi

AU - Biswal, Nrusingh C.

AU - Wang, Tianheng

AU - Kumavor, Patrick

AU - Karimeddini, Mozafareddin

AU - Sanders, Melinda

AU - Brewer, Molly

AU - Zhu, Quing

PY - 2011

Y1 - 2011

N2 - Ovarian cancer has the lowest survival rate of the gynecologic cancers with a 5-year survival of about 50% in the United States. With current screening and diagnostic abilities for ovarian cancers, most of the diagnosed patients are already with advanced stages and the majority of them will die of this deadly disease. In this paper, we report a multimodal imaging approach which combines optical coherence tomography (OCT) and positron detection for early ovarian cancer detection. The dual modality system has the capability of providing both functional and morphological images simultaneously. While the positron detection provides the metabolism activity of the ovary due to the uptake of radiotracer, the OCT provides the high resolution (25μm X 25μm X 12μm - longitudinal X lateral X axial in air) structural imaging at 20k A-lines per second. Total 18 ovaries obtained from 10 patients classified as normal, abnormal and malignant ovarian tissues were characterized ex vivo. Positron counts of 1.2-fold higher was found between abnormal and normal ovaries and 3~30-fold higher was found between malignant and normal ovaries. OCT imaging of malignant and abnormal ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in the ovary.

AB - Ovarian cancer has the lowest survival rate of the gynecologic cancers with a 5-year survival of about 50% in the United States. With current screening and diagnostic abilities for ovarian cancers, most of the diagnosed patients are already with advanced stages and the majority of them will die of this deadly disease. In this paper, we report a multimodal imaging approach which combines optical coherence tomography (OCT) and positron detection for early ovarian cancer detection. The dual modality system has the capability of providing both functional and morphological images simultaneously. While the positron detection provides the metabolism activity of the ovary due to the uptake of radiotracer, the OCT provides the high resolution (25μm X 25μm X 12μm - longitudinal X lateral X axial in air) structural imaging at 20k A-lines per second. Total 18 ovaries obtained from 10 patients classified as normal, abnormal and malignant ovarian tissues were characterized ex vivo. Positron counts of 1.2-fold higher was found between abnormal and normal ovaries and 3~30-fold higher was found between malignant and normal ovaries. OCT imaging of malignant and abnormal ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in the ovary.

KW - gynecology

KW - intraoperative probe

KW - optical coherence tomography

KW - ovarian cancer

KW - positron detection

UR - https://www.scopus.com/pages/publications/79955438873

U2 - 10.1117/12.878860

DO - 10.1117/12.878860

M3 - Conference contribution

AN - SCOPUS:79955438873

SN - 9780819484291

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Multimodal Biomedical Imaging VI

T2 - Multimodal Biomedical Imaging VI

Y2 - 22 January 2011 through 23 January 2011

ER -

A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization

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Keywords

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