A human STAT1 gain-of-function mutation impairs CD8+ T cell responses against gammaherpesvirus 68

Keyphrases

• CD8+ T Cells 100%
• Gammaherpesvirus 100%
• STAT1 Gain-of-function mutation 100%
• Immunodeficiency 75%
• Leukocytes 50%
• CD4+ 50%
• Interferon-γ 50%
• Herpesvirus 50%
• Herpesvirus Infection 50%
• Infection Control 50%
• Viral Pathogenesis 50%
• Candida 50%
• Antigen-specific CD8+ T Cells 50%
• STAT1 mutation 50%
• Impaired Control 50%
• STAT1 Gain of Function 50%
• Knock-in Mouse Model 25%
• Immune Response 25%
• Antigen-specific 25%
• Autosomal Dominant 25%
• T Helper 17 (Th17) 25%
• Gain-of-function mutation 25%
• Decreased Expression 25%
• Coiled-coil Domain 25%
• Herpes Simplex Virus Type 1 (HSV-1) 25%
• Inoculation 25%
• Antiviral T Cells 25%
• Primary Macrophages 25%
• Immunological Methods 25%
• Stimulator of Interferon Genes (STING) 25%
• Antiviral Immunity 25%
• Increased Vulnerability 25%
• Day 14 25%
• Antigen-specific T Cell Response 25%
• Cell-intrinsic Immunity 25%
• Primary Fibroblasts 25%
• Littermate Controls 25%
• Heterozygous Mice 25%
• Autosomal Dominant mutation 25%
• Pathogenesis Studies 25%
• Th17 Response 25%
• Bone Marrow chimeric Mice 25%
• Chronic mucocutaneous Candidiasis 25%

Immunology and Microbiology

• Cytotoxic T-Cell 100%
• STAT1 100%
• Gammaherpesvirus 100%
• Gain of Function Mutation 100%
• Wild Type 26%
• Antigen Specificity 26%
• Herpesviridae 26%
• Immunodeficiency 20%
• T Cell 13%
• T-Helper Cell 13%
• Leukocyte 13%
• Autosomal Dominant Inheritance 13%
• Interferon Gamma 13%
• Viral Pathogenesis 13%
• Candida 13%
• Macrophage 6%
• Immune Response 6%
• Human Alphaherpesvirus 1 6%
• Immunological Method 6%
• Interferon-Stimulated Gene 6%
• Antiviral Immunity 6%
• Intrinsic Immunity 6%
• Chronic Mucocutaneous Candidiasis 6%
• Fibroblast 6%