Abstract
Killer inhibitory receptors (KIRs) are transmembrane glycoproteins, expressed on NK cells and a small subset of T cells, that inhibit cell- mediated cytotoxicity upon binding to polymorphic MHC class I determinants on target cells. Although human KIRs specific for HLA-C and HLA-B molecules have been characterized, none have been shown to interact with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3.
| Original language | English |
|---|---|
| Pages (from-to) | 3098-3101 |
| Number of pages | 4 |
| Journal | Journal of Immunology |
| Volume | 156 |
| Issue number | 9 |
| State | Published - May 1 1996 |