Keyphrases
Niemann-Pick C1-like 1 (NPC1L1)
100%
NP-C
100%
Neuronal Model
100%
Human iPSC
100%
Isogenic
20%
Unesterified Cholesterol
20%
NPC2
20%
Mitochondrial Dysfunction
20%
Cell-based
10%
Neurodegeneration
10%
Disease Pattern
10%
Pathophysiology
10%
Pathological Features
10%
Cell Behavior
10%
Autosomal Recessive
10%
Lipids
10%
Lysosome
10%
Cholesterol
10%
Neurodegenerative Diseases
10%
Cholesterol Levels
10%
Axonal Trafficking
10%
Cellular Cholesterol
10%
Endolysosomal
10%
High-throughput Screening
10%
Cellular Mechanisms
10%
Neuronal Loss
10%
Therapeutic Agents
10%
Progressive Neurodegeneration
10%
Hydroxypropyl-β-cyclodextrin (HP-β-CD)
10%
Cholesterol Homeostasis
10%
Pathogenic Mechanism
10%
Appropriate Therapy
10%
Late Endosome
10%
Potential Therapeutics
10%
High-throughput
10%
In Vitro System
10%
Childhood-onset
10%
IPSC-derived Neurons
10%
Neurodegenerative
10%
Pick's Disease
10%
Patient Fibroblasts
10%
Cholesterol Accumulation
10%
Chemical Screen
10%
GM2 Ganglioside
10%
New Cell Line
10%
Neuron Model
10%
Trafficking Defect
10%
Ganglioside GM3
10%
Lysosome Transport
10%
Neuroscience
Pick's Disease
100%
Cell Line
66%
Neurodegeneration
33%
In Vitro
33%
Neurodegenerative Disorder
33%
Cyclodextrin
33%
Cell Function
33%
Nerve Cell Degeneration
33%
Lysosome
33%
Ganglioside GM2
33%
Ganglioside GM3
33%
Fibroblast
33%
Biochemistry, Genetics and Molecular Biology
Induced Pluripotent Stem Cell
100%
NPC1
100%
Niemann-Pick Disease
100%
Mitochondrial Disorder
20%
Cholesterol Level
10%
Cell Function
10%
Lipid
10%
Lysosome
10%
Autosomal Recessive Inheritance
10%
Nerve Cell Degeneration
10%
GM3
10%
Fibroblast
10%
Cyclodextrin
10%
Ganglioside
10%
Cholesterol Homeostasis
10%